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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.
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<Amphetamines, effect, norepinephrine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;
|
<Amphetamines, mechanism, phenobarbital>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;
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<Amphetamines, mechanism, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.
|
<propoxyphene, effect, amphetamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.
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<Amphetamines, effect, veratrum alkaloids>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly.
|
<Intestinal adsorbents, mechanism, Acarbose>, <charcoal, mechanism, Acarbose>, <amylase, mechanism, Acarbose>, <pancreatin, mechanism, Acarbose>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment.
|
<Acarbose, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin.
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<metformin, mechanism, Acarbose>, <Acarbose, mechanism, metformin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine;
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<Cyclopentolate, effect, carbachol>, <Cyclopentolate, effect, pilocarpine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Co-medications that induce CYP 3A4 (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, or St. John s wort) may significantly decrease exposure to exemestane.
|
<rifampicin, mechanism, exemestane>, <phenytoin, mechanism, exemestane>, <carbamazepine, mechanism, exemestane>, <phenobarbital, mechanism, exemestane>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
A case report of one patient taking amiodarone 200 mg and indinavir 800 mg three times a day resulted in increases in amiodarone concentrations from 0.9 mg/L to 1.3 mg/L.
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<amiodarone, mechanism, indinavir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Monitoring for amiodarone toxicity and serial measurement of amiodarone serum concentration during concomitant protease inhibitor therapy should be considered.
|
<amiodarone, advise, protease inhibitor>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Histamine H2 antagonists: Cimetidine inhibits CYP3A4 and can increase serum amiodarone levels.
|
<Histamine H2 antagonists, mechanism, Cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
On administration of oral amiodarone, the need for digitalis therapy should be reviewed and the dose reduced by approximately 50% or discontinued.
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<amiodarone, advise, digitalis>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction).
|
<Nafazodone, advise, Xanax>, <fluvoxamine, advise, Xanax>, <cimetidine, advise, Xanax>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Concomitant use of calcium supplements and L-lysine may increase calcium absorption
|
<calcium, mechanism, L-lysine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within14 days following use of monoamine oxidase inhibitors.
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<sympathomimetic amines, effect, monoamine oxidase inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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DIDREX should not be used concomitantly with other CNS stimulants.
|
<DIDREX, advise, CNS stimulants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Amphetamines may decrease the hypotensive effect of antihypertensives.
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<Amphetamines, effect, antihypertensives>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Amphetamines may enhance the effects of tricyclic antidepressants.
|
<Amphetamines, effect, tricyclic antidepressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Urinary acidifying agents decrease blood levels and increase excretion of amphetamines.
|
<Urinary acidifying, mechanism, amphetamines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone.
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<labetalol HCl, effect, tricyclic antidepressants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine has been shown to increase the bioavailability of labetalol HCl.
|
<Cimetidine, mechanism, labetalol HCl>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl.
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<halothane, effect, labetalol HCl>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure.
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<labetalol HCl, effect, halothane>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect.
|
<Labetalol HCl, effect, nitroglycerin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.
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<labetalol HCl, effect, nitroglycerin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.
|
<labetalol, advise, calcium antagonist>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In clinical trials in patients undergoing PTCA/PCI, co-administration of Angiomax with heparin, warfarin, thrombolytics or glycoprotein IIb/IIIa inhibitors was associated with increased risks of major bleeding events compared to patients not receiving these concomitant medications.
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<Angiomax, effect, heparin>, <Angiomax, effect, warfarin>, <Angiomax, effect, thrombolytics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.
|
<epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.
|
<Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Drug Interactions with Beta-Blockers: Concomitant use of fenoldopam with beta-blockers should be avoided.
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<fenoldopam, advise, beta-blockers>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Apraclonidine should not be used in patients receiving MAO inhibitors..
|
<Apraclonidine, advise, MAO inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although no specific drug interactions with topical glaucoma drugs or systemic medications were identified in clinical studies of IOPIDINE 0.5% Ophthalmic Solution, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, anesthetics) should be considered.
|
<IOPIDINE, advise, CNS depressants>, <IOPIDINE, advise, alcohol>, <IOPIDINE, advise, barbiturates>, <IOPIDINE, advise, opiates>, <IOPIDINE, advise, sedatives>, <IOPIDINE, advise, anesthetics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.
|
<Tricyclic antidepressants, effect, clonidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
An additive hypotensive effect has been reported with the combination of systemic clonidine and neuroleptic therapy.
|
<clonidine, effect, neuroleptic>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since apraclonidine may reduce pulse and blood pressure, caution in using drugs such as beta-blockers (ophthalmic and systemic), antihypertensives, and cardiac glycosides is advised.
|
<apraclonidine, advise, beta-blockers>, <apraclonidine, advise, antihypertensives>, <apraclonidine, advise, cardiac glycosides>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When Bezalip or Bezalip retard is used at the same time as other medicines or substances the following interactions must be taken into account: - Bezalip and Bezalip retard may enhance the action of anticoagulants of the coumarin type.
|
<Bezalip, effect, anticoagulants of the coumarin type>, <Bezalip retard, effect, anticoagulants of the coumarin type>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
For this reason, the dose of the anticoagulant should be reduced by 30 - 50% at the start of treatment with Bezalip or Bezalip retard and then titrated according to the blood clotting parameters
|
<anticoagulant, advise, Bezalip>, <anticoagulant, advise, Bezalip>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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- The action of sulphonylureas and insulin may be enhanced by Bezalip or Bezalip retard.
|
<sulphonylureas, effect, Bezalip>, <sulphonylureas, effect, Bezalip retard>, <insulin, effect, Bezalip>, <insulin, effect, Bezalip retard>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- In isolated cases, a pronounced though reversible, impairment of renal function (accompanied by a corresponding increase in the serum creatinine level) has been reported in organ transplant patients receiving immuno-suppressant therapy and concomitant bezafibrate.
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<immuno-suppressant, effect, bezafibrate>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- When Bezalip or Bezalip retard is used concurrently with anion-exchange resins (e.g. cholestryramine), an interval of at least 2 hours should be maintained between the two medicines, since the absorption of Bezalip or Bezalip retard is impaired
|
<Bezalip, advise, anion-exchange resins>, <Bezalip, advise, cholestryramine>, <Bezalip retard, advise, anion-exchange resins>, <Bezalip retard, advise, cholestryramine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Perhexiline hydrogen maleate or MAO-inhibitors (with hepatotoxic potential) must not be administered together with Bezalip or Bezalip retard.
|
<Perhexiline hydrogen maleate, advise, Bezalip>, <Perhexiline hydrogen maleate, advise, Bezalip retard>, <MAO-inhibitors, advise, Bezalip>, <MAO-inhibitors, advise, Bezalip retard>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Although there are no study data to evaluate the possibility, nitric oxide donor compounds, including sodium nitroprusside and nitroglycerin, may have an additive effect with INOmax on the risk of developing methemoglobinemia.
|
<nitric oxide donor compounds, effect, INOmax>, <sodium nitroprusside, effect, INOmax>, <nitroglycerin, effect, INOmax>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant oral administration of ketoconazole (a known inhibitor of CYP3A4 activity in the liver and in the intestinal mucosa) caused an eight-fold increase of the systemic exposure to oral budesonide.
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<ketoconazole, mechanism, budesonide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If treatment with inhibitors of CYP3A4 activity (such as ketoconazole, intraconazole, ritonavir, indinavir, saquinavir, erythromycin, etc.) is indicated, reduction of the budesonide dose should be considered.
|
<ketoconazole, advise, budesonide>, <intraconazole, advise, budesonide>, <ritonavir, advise, budesonide>, <indinavir, advise, budesonide>, <saquinavir, advise, budesonide>, <erythromycin, advise, budesonide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Tagamet, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.
|
<Tagamet, mechanism, warfarin-type anticoagulants>, <Tagamet, mechanism, phenytoin>, <Tagamet, mechanism, propranolol>, <Tagamet, mechanism, nifedipine>, <Tagamet, mechanism, chlordiazepoxide>, <Tagamet, mechanism, diazepam>, <Tagamet, mechanism, tricyclic antidepressants>, <Tagamet, mechanism, lidocaine>, <Tagamet, mechanism, theophylline>, <Tagamet, mechanism, metronidazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when Tagamet is administered concomitantly.
|
<anticoagulant, advise, Tagamet>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, a crossover study in healthy subjects receiving either Tagamet 300 mg q.i.d. or 800 mg h.s. concomitantly with a 300 mg b.i.d. dosage of theophylline (Theo-Dur , Key Pharmaceuticals, Inc.) demonstrated less alteration in steady-state theophylline peak serum levels with the 800 mg h.s. regimen, particularly in subjects aged 54 years and older.
|
<Tagamet, mechanism, theophylline>, <Tagamet, mechanism, Theo-Dur>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant use of ELLENCE with other cardioactive compounds that could cause heart failure (e.g., calcium channel blockers), requires close monitoring of cardiac function throughout treatment.
|
<ELLENCE, advise, calcium channel blockers>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine increased the AUC of epirubicin by 50%.
|
<Cimetidine, mechanism, epirubicin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine treatment should be stopped during treatment with ELLENCE.
|
<Cimetidine, advise, ELLENCE>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
MAO inhibitors prolong and intensify the effects of antihistamines.
|
<MAO inhibitors, effect, antihistamines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant use of antihistamines with alcohol, tricyclic antidepressants, barbiturates, or other central nervous system depressants may have an additive effect.
|
<antihistamines, effect, alcohol>, <antihistamines, effect, tricyclic antidepressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, central nervous system depressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When sympathomimetic drugs are given to patients receiving monoamine oxidase inhibitors, hypertensive reactions, including hypertensive crises, may occur.
|
<sympathomimetic drugs, effect, monoamine oxidase inhibitors>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The antihypertensive effects of methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics.
|
<methyldopa, effect, sympathomimetics>, <mecamylamine, effect, sympathomimetics>, <reserpine, effect, sympathomimetics>, <veratrum alkaloids, effect, sympathomimetics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Beta-adrenergic blocking agents may also interact with sympathomimetics.
|
<Beta-adrenergic blocking agents, int, sympathomimetics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.
|
<pseudoephedrine, effect, digitalis>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Antacids increase the rate of absorption of pseudoephedrine, while kaolin decreases it.
|
<Antacids, mechanism, pseudoephedrine>, <pseudoephedrine, mechanism, kaolin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).
|
<Dexbrompheniramine, int, alcohol>, <Dexbrompheniramine, int, CNS depressants>, <Dexbrompheniramine, int, anticholinergics>, <Dexbrompheniramine, int, monoamine oxidase (MAO) inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In a Phase I trial using escalating doses of TAXOL (110-200 mg/m2) and cisplatin (50 or 75 mg/m2) given as sequential infusions, myelosuppression was more profound when TAXOL was given after cisplatin than with the alternate sequence (ie, TAXOL before cisplatin).
|
<TAXOL, effect, cisplatin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Pharmacokinetic data from these patients demonstrated a decrease in paclitaxel clearance of approximately 33% when TAXOL was administered following cisplatin.
|
<TAXOL, mechanism, cisplatin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Reports in the literature suggest that plasma levels of doxorubicin (and its active metabolite doxorubicinol) may be increased when paclitaxel and doxorubicin are used in combination.
|
<paclitaxel, mechanism, doxorubicin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Hypersensitivity Reactions: Patients with a history of severe hypersensitivity reactions to products containing Cremophor EL (eg, cyclosporin for injection concentrate and teniposide for injection concentrate) should not be treated with TAXOL.
|
<cyclosporin, advise, TAXOL>, <teniposide, advise, TAXOL>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Immediate and Extended Release Tablets The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
|
<sulfonylureas, effect, nonsteroidal anti-inflammatory agents>, <sulfonylureas, effect, azoles>, <sulfonylureas, effect, salicylates>, <sulfonylureas, effect, sulfonamides>, <sulfonylureas, effect, chloramphenicol>, <sulfonylureas, effect, probenecid>, <sulfonylureas, effect, coumarins>, <sulfonylureas, effect, monoamine oxidase inhibitors>, <sulfonylureas, effect, beta adrenergic blocking agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.
|
<miconazole, int, hypoglycemic agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers.
|
<fluconazole, int, glipizide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).
|
<glipizide, mechanism, fluconazole>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control).
|
<barbiturates, effect, contraceptives>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
ACE-inhibitors Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.
|
<NSAIDs, effect, ACE-inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
|
<NSAIDs, advise, ACE-inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Aspirin: When Lodine is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered.
|
<Lodine, mechanism, aspirin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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however, as with other NSAIDs, concomitant administration of Lodine and aspirin is not generally recommended because of the potential of increased adverse effects.
|
<Lodine, advise, aspirin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cyclosporine, Digoxin, Methotrexate Lodine, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity.
|
<Lodine, mechanism, cyclosporine>, <Lodine, mechanism, digoxin>, <Lodine, mechanism, methotrexate>, <NSAIDs, mechanism, cyclosporine>, <NSAIDs, mechanism, digoxin>, <NSAIDs, mechanism, methotrexate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Nevertheless, clinical studies, as well as postmarketing observations have shown that Lodine can reduce the natriuretic effect of furosemide and thiazides in some patients.
|
<Lodine, effect, furosemide>, <Lodine, effect, thiazides>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance.
|
<NSAIDs, mechanism, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
|
<NSAIDs, effect, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Phenylbutazone: Phenylbutazone causes increase (by about 80%) in the free fraction of etodolac.
|
<Phenylbutazone, mechanism, etodolac>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Although in vivo studies have not been done to see if etodolac clearance is changed by coadministration of phenylbutazone, it is not recommended that they be coadministered.
|
<etodolac, advise, phenylbutazone>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone.
|
<warfarin, effect, NSAIDs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Lodine (etodolac capsules and tablets) results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin.
|
<warfarin, mechanism, Lodine>, <warfarin, mechanism, etodolac>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in etodolac-treated patients receiving concomitant warfarin therapy.
|
<etodolac, effect, warfarin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In patients given very high doses (3900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.
|
<aspirin, mechanism, nizatidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If additional adrenergic drugs are to be administered by any route, they should be used with caution because the pharmacologically predictable sympathetic effects of BROVANA may be potentiated.
|
<adrenergic drugs, advise, BROVANA>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant treatment with methylxanthines (aminophylline, theophylline), steroids, or diuretics may potentiate any hypokalemic effect of adrenergic agonists.
|
<methylxanthines, effect, adrenergic agonists>, <aminophylline, effect, adrenergic agonists>, <theophylline, effect, adrenergic agonists>, <steroids, effect, adrenergic agonists>, <diuretics, effect, adrenergic agonists>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The ECG changes and/or hypokalemia that may result from the administration of non-potassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.
|
<non-potassium sparing diuretics, effect, beta-agonists>, <loop diuretics, effect, beta-agonists>, <thiazide diuretics, effect, beta-agonists>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Although the clinical significance of these effects is not known, caution is advised in the co-administration of beta-agonists with non-potassium sparing diuretics.
|
<beta-agonists, advise, non-potassium sparing diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
BROVANA, as with other beta2-agonists, should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors, tricyclic antidepressants, or drugs known to prolong the QTc interval because the action of adrenergic agonists on the cardiovascular system may be potentiated by these agents.
|
<BROVANA, advise, monoamine oxidase inhibitors>, <BROVANA, advise, tricyclic antidepressants>, <beta2-agonists, advise, monoamine oxidase inhibitors>, <beta2-agonists, advise, tricyclic antidepressants>, <monoamine oxidase inhibitors, effect, adrenergic agonists>, <tricyclic antidepressants, effect, adrenergic agonists>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Beta-adrenergic receptor antagonists (beta-blockers) and BROVANA may interfere with the effect of each other when administered concurrently.
|
<Beta-adrenergic receptor antagonists, effect, BROVANA>, <beta-blockers, effect, BROVANA>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Beta-blockers not only block the therapeutic effects of beta-agonists, but may produce severe bronchospasm in COPD patients.
|
<Beta-blockers, effect, beta-agonists>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Additive CNS depression may occur when antihistamines are administered concomitantly with other CNS depressants including barbiturates, tranquilizers, and alcohol.
|
<antihistamines, effect, CNS depressants>, <antihistamines, effect, barbiturates>, <antihistamines, effect, tranquilizers>, <antihistamines, effect, alcohol>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients receiving antihistamines should be advised against the concurrent use of other CNS depressant drugs.
|
<antihistamines, advise, CNS depressant drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of antihistamines.
|
<Monoamine oxidase (MAO) inhibitors, effect, antihistamines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect .
|
<doxapram, effect, sympathomimetic>, <doxapram, effect, monoamine oxidase inhibiting drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In patients who have received muscle relaxants, doxapram may temporarily mask the residual effects of muscle relaxant drugs.
|
<doxapram, effect, muscle relaxant drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The effects of ERGOMAR may be potentiated by triacetyloleandomycin which inhibits the metabolism of ergotamine.
|
<ERGOMAR, mechanism, triacetyloleandomycin>, <triacetyloleandomycin, mechanism, ergotamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The pressor effects of ERGOMAR and other vasoconstrictor drugs can combine to cause dangerous hypertension.
|
<ERGOMAR, effect, vasoconstrictor drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported.
|
<xanthine bronchodilators, effect, sympathomimetic bronchodilators>, <theophylline, effect, sympathomimetic bronchodilators>, <ephedrine, effect, sympathomimetic bronchodilators>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline .
|
<dyphylline, mechanism, probenecid>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, in patients treated with oral carbonic anhydrase inhibitors, rare instances of drug interactions have occurred with high-dose salicylate therapy.
|
<carbonic anhydrase inhibitors, int, salicylate>
|
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