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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients who are treated with ZYVOX and concomitant serotonergic agents should be closely observed for signs and symptoms of serotonin syndrome (e.g., cognitive dysfunction, hyperpyrexia, hyperreflexia, incoordination).
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<ZYVOX, effect, serotonergic agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If any signs or symptoms occur physicians should consider discontinuation of either one or both agents (ZYVOX or concomitant serotonergic agents).
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<ZYVOX, advise, serotonergic agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coumarin Anticoagulants Altered coagulation parameters and/or bleeding have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon.
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<capecitabine, effect, coumarin-derivative anticoagulants>, <capecitabine, effect, phenprocoumon>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients taking coumarin-derivative anticoagulants concomitantly with capecitabine should be monitored regularly for alterations in their coagulation parameters (PT or INR).
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<coumarin-derivative anticoagulants, advise, capecitabine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin.
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<5-fluorouracil, mechanism, leucovorin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.
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<leucovorin, effect, fluorouracil>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly are increased by chronic administration of high doses of phenobarbital.
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<cyclophosphamide, mechanism, phenobarbital>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cyclophosphamide treatment, which causes a marked and persistent inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride.
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<Cyclophosphamide, effect, succinylcholine chloride>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Iodine or iodine excess may decrease the effect of Carbimazole, and an iodine deficiency can increase the effect of Carbimazole.
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<Iodine, effect, Carbimazole>, <iodine, effect, Carbimazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Serum concentration of digoxin and digitoxin may increase when patients take antithyroid agents.
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<digoxin, mechanism, antithyroid agents>, <digitoxin, mechanism, antithyroid agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Antithyroid agents may decrease thyroidal uptake of sodium iodide I131, a rebound in uptake may occur up to 5 days after sudden withdrawal of Carbimazole.
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<Antithyroid agents, effect, sodium iodide I131>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Based on anecdotal reports, there may be an interaction between buprenorphine and benzodiazepines.
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<buprenorphine, int, benzodiazepines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There have been a number of reports in the post-marketing experience of coma and death associated with the concomitant intravenous misuse of buprenorphine and benzodiazepines by addicts.
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<buprenorphine, effect, benzodiazepines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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SUBUTEX and SUBOXONE should be prescribed with caution to patients on benzodiazepines or other drugs that act on the central nervous system, regardless of whether these drugs are taken on the advice of a physician or are taken as drugs of abuse.
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<SUBUTEX, advise, benzodiazepines>, <SUBOXONE, advise, benzodiazepines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients should be warned of the potential danger of the intravenous self-administration of benzodiazepines while under treatment with SUBOXONE or SUBUTEX.
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<benzodiazepines, advise, SUBOXONE>, <benzodiazepines, advise, SUBUTEX>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Blood levels of hydrodolasetron increased 24% when dolasetron was coadministered with cimetidine (nonselective inhibitor of cytochrome P-450) for 7 days, and decreased 28% with coadministration of rifampin (potent inducer of cytochrome P-450) for 7 days.
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<dolasetron, mechanism, cimetidine>, <dolasetron, mechanism, rifampin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Clearance of hydrodolasetron decreased by about 27% when dolasetron mesylate was administered intravenously concomitantly with atenolol.
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<dolasetron mesylate, mechanism, atenolol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chlorprothixene may increase the plasma-level of concomitantly given lithium.
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<Chlorprothixene, mechanism, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively.
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<chlorprothixene, advise, opioids>, <chlorprothixene, effect, opioids>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Avoid the concomitant use of chlorprothixene and tramadol (Ultram).
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<chlorprothixene, advise, tramadol>, <chlorprothixene, advise, Ultram>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Consider additive sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates.
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<chlorprothixene, effect, benzodiazepines>, <chlorprothixene, effect, barbituates>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Exert particular caution in combining chlorprothixene with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma.
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<chlorprothixene, advise, anticholinergic drugs>, <chlorprothixene, advise, tricyclic antidepressants>, <chlorprothixene, advise, antiparkinsonian agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Use in Conjunction with Other Antiepileptic Drugs: The addition of Felbatol to antiepileptic drugs (AEDs) affects the steady-state plasma concentrations of AEDs.
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<Felbatol, mechanism, antiepileptic drugs>, <Felbatol, mechanism, AEDs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Specific Effects of Felbatol on Other Antiepileptic Drugs Phenytoin: Felbatol causes an increase in steady-state phenytoin plasma concentrations.
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<Felbatol, mechanism, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Increasing the felbamate dose to 1800 mg/day in six of these subjects increased the steady-state phenytoin Cmin to 25 7 micrograms/mL.
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<felbamate, mechanism, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In order to maintain phenytoin levels, limit adverse experiences, and achieve the felbamate dose of 3600 mg/day, a phenytoin dose reduction of approximately 40% was necessary for eight of these 10 subjects.
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<felbamate, advise, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Carbamazepine: Felbatol causes a decrease in the steady-state carbamazepine plasma concentrations and an increase in the steady-state carbamazepine epoxide plasma concentration.
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<Felbatol, mechanism, carbamazepine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The carbamazepine steady-state Cmin decreased 31% to 5 1 micrograms/mL when felbamate (3000 mg/day, divided into three doses) was coadministered.
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<carbamazepine, mechanism, felbamate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Valproate: Felbatol causes an increase in steady-state valproate concentrations.
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<Felbatol, mechanism, valproate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Increasing the felbamate dose to 2400 mg/day increased the steadystate valproate Cmin to 96 25 micrograms/mL.
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<felbamate, mechanism, valproate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Phenobarbital: Coadministration of felbamate with phenobarbital causes an increase in phenobarbital plasma concentrations, In 12 otherwise healthy male volunteers ingesting phenobarbital, the steady-state trough (Cmin) phenobarbital concentration was 14.2 micrograms/mL.
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<felbamate, mechanism, phenobarbital>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Effects of Other Antiepileptic Drugs on Felbatol Phenytoin: Phenytoin causes an approximate doubling of the clearance of Felbatol (felbamate) at steady state and, therefore, the addition of phenytoin causes an approximate 45% decrease in the steady-state trough concentrations of Felbatol as compared to the same dose of Felbatol given as monotherapy.
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<Phenytoin, mechanism, Felbatol>, <Phenytoin, mechanism, felbamate>, <phenytoin, mechanism, Felbatol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Carbamazepine: Carbamazepine causes an approximate 50% increase in the clearance of Felbatol at steady state and, therefore, the addition of carbamazepine results in an approximate 40% decrease in the steady-state trough concentrations of Felbatol as compared to the same dose of Felbatol given as monotherapy.
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<Carbamazepine, mechanism, Felbatol>, <carbamazepine, mechanism, Felbatol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Phenobarbital: It appears that phenobarbital may reduce plasma felbamate concentrations.
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<phenobarbital, mechanism, felbamate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Felbamate treatment resulted in a 42% decrease in the gestodene AUC 0-24, but no clinically relevant effect was observed on the pharmacokinetic parameters of ethinyl estradiol.
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<Felbamate, mechanism, gestodene>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chirocaine should be used with caution in patients receiving other local anesthetics or agents structurally related to amide-type local anesthetics since the toxic effects of these drugs could be additive.
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<Chirocaine, advise, anesthetics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although no clinical studies have been conducted, it is likely that the metabolism of levobupivacaine may be affected by the known CYP3A4 inducers (such as phenytoin, phenobarbital, rifampin), CYP3A4 inhibitors (azole antimycotics e.g., ketoconazole;
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<levobupivacaine, mechanism, phenytoin>, <levobupivacaine, mechanism, phenobarbital>, <levobupivacaine, mechanism, rifampin>, <levobupivacaine, mechanism, ketoconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin.
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<aspirin, mechanism, ketoprofen>, <aspirin, mechanism, ketoprofen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, concurrent use of aspirin and ketoprofen is not recommended.
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<aspirin, advise, ketoprofen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.
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<Hydrochlorothiazide, effect, ketoprofen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs.
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<ketoprofen, advise, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding.
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<Probenecid, mechanism, ketoprofen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, the combination of ketoprofen and probenecid is not recommended.
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<ketoprofen, advise, probenecid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity.
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<Ketoprofen, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels.
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<Nonsteroidal anti-inflammatory agents, mechanism, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium.
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<ketoprofen, advise, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Interactions for Vitamin B3 (Niacin): Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.
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<Nicotinic acid, effect, ganglionic blocking agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid.
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<aspirin, mechanism, nicotinic acid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-administration of irbesartan reduced aliskiren Cmax up to 50% after multiple dosing.
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<irbesartan, mechanism, aliskiren>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-administration of atorvastatin resulted in about a 50% increase in aliskiren Cmax and AUC after multiple dosing.
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<atorvastatin, mechanism, aliskiren>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Ketoconazole: Co-administration of 200 mg twice-daily ketoconazole with aliskiren resulted in an approximate 80% increase in plasma levels of aliskiren.
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<ketoconazole, mechanism, aliskiren>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide: When aliskiren was co-administered with furosemide, the AUC and Cmax of furosemide were reduced by about 30% and 50%, respectively.
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<aliskiren, mechanism, furosemide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Acetaminophen: May increase plasma concentration of synthetic estrogens, possibly by inhibiting conjugation.
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<Acetaminophen, mechanism, synthetic estrogens>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Combination hormonal contraceptives may also decrease the plasma concentration of acetaminophen.
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<hormonal contraceptives, mechanism, acetaminophen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Acitretin: Interferes with the contraceptive effect of microdosed progestin-containing minipill preparations.
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<Acitretin, effect, progestin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Aminoglutethimide: May increase CYP metabolism of progestins leading to possible decrease in contraceptive effectiveness.
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<Aminoglutethimide, mechanism, progestins>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anticoagulants: Combination hormonal contraceptives may increase or decrease the effects of coumarin derivatives.
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<hormonal contraceptives, effect, coumarin derivatives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anticonvulsants (carbamazepine, felbamate, phenobarbital, phenytoin, topiramate): Increase the metabolism of ethinyl estradiol and/or some progestins, leading to possible decrease in contraceptive effectiveness.
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<Anticonvulsants, mechanism, ethinyl estradiol>, <Anticonvulsants, mechanism, progestins>, <carbamazepine, mechanism, ethinyl estradiol>, <carbamazepine, mechanism, progestins>, <felbamate, mechanism, ethinyl estradiol>, <felbamate, mechanism, progestins>, <phenobarbital, mechanism, ethinyl estradiol>, <phenobarbital, mechanism, progestins>, <phenytoin, mechanism, ethinyl estradiol>, <phenytoin, mechanism, progestins>, <topiramate, mechanism, ethinyl estradiol>, <topiramate, mechanism, progestins>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Ascorbic acid: Doses of ascorbic acid (vitamin C) 1 g/day have been reported to increase plasma concentration of synthetic estrogens by ~47%, possibly by inhibiting conjugation;
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<ascorbic acid, mechanism, synthetic estrogens>, <vitamin C, mechanism, synthetic estrogens>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Atorvastatin: Atorvastatin increases the AUC for norethindrone and ethinyl estradiol.
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<Atorvastatin, mechanism, norethindrone>, <Atorvastatin, mechanism, ethinyl estradiol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Benzodiazepines: Combination hormonal contraceptives may decrease the clearance of some benzodiazepines (alprazolam, chlordiazepoxide, diazepam) and increase the clearance of others (lorazepam, oxazepam, temazepam).
|
<hormonal contraceptives, mechanism, benzodiazepines>, <hormonal contraceptives, mechanism, alprazolam>, <hormonal contraceptives, mechanism, chlordiazepoxide>, <hormonal contraceptives, mechanism, diazepam>, <hormonal contraceptives, mechanism, lorazepam>, <hormonal contraceptives, mechanism, oxazepam>, <hormonal contraceptives, mechanism, temazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Clofibric acid: Combination hormonal contraceptives may increase the clearance of clofibric acid.
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<hormonal contraceptives, mechanism, clofibric acid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cyclosporine: Combination hormonal contraceptives may inhibit the metabolism of cyclosporine, leading to increased plasma concentrations;
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<hormonal contraceptives, mechanism, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Griseofulvin: Griseofulvin may induce the metabolism of combination hormonal contraceptives causing menstrual changes;
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<Griseofulvin, mechanism, combination hormonal contraceptives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Morphine: Combination hormonal contraceptives may increase the clearance of morphine.
|
<hormonal contraceptives, mechanism, morphine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Non-nucleoside reverse transcriptase inhibitors (NNRTIs): Nevirapine may decrease plasma levels of combination hormonal contraceptives;
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<Nevirapine, mechanism, combination hormonal contraceptives>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Prednisolone: Ethinyl estradiol may inhibit the metabolism of prednisolone, leading to increased plasma concentrations.
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<Ethinyl estradiol, mechanism, prednisolone>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Protease inhibitors: Amprenavir, lopinavir, nelfinavir, and ritonavir have been shown to decrease plasma levels of combination hormonal contraceptives;
|
<Amprenavir, mechanism, combination hormonal contraceptives>, <lopinavir, mechanism, combination hormonal contraceptives>, <nelfinavir, mechanism, combination hormonal contraceptives>, <ritonavir, mechanism, combination hormonal contraceptives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Indinavir has been shown to increase plasma levels of combination hormonal contraceptives.
|
<Indinavir, mechanism, combination hormonal contraceptives>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Rifampin: Rifampin increases the metabolism of ethinyl estradiol and some progestins (norethindrone) resulting in decreased contraceptive effectiveness and increased menstrual irregularities.
|
<Rifampin, mechanism, ethinyl estradiol>, <Rifampin, mechanism, progestins>, <Rifampin, mechanism, norethindrone>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Salicylic acid: Combination hormonal contraceptives may increase the clearance of salicylic acid.
|
<hormonal contraceptives, mechanism, salicylic acid>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Selegiline: Combination hormonal contraceptives may increase the serum concentration of selegiline.
|
<Combination hormonal contraceptives, mechanism, selegiline>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Theophylline: Ethinyl estradiol may inhibit the metabolism of theophylline, leading to increased plasma concentrations.
|
<Ethinyl estradiol, mechanism, theophylline>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tricyclic antidepressants (amitriptyline, imipramine, nortriptyline): Metabolism may be inhibited by combination hormonal contraceptives, increasing plasma levels of antidepressant;
|
<Tricyclic antidepressants, mechanism, combination hormonal contraceptives>, <amitriptyline, mechanism, combination hormonal contraceptives>, <imipramine, mechanism, combination hormonal contraceptives>, <nortriptyline, mechanism, combination hormonal contraceptives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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ETHANOL / NUTRITION / HERB INTERACTIONS: Food: CNS effects of caffeine may be enhanced if combination hormonal contraceptives are used concurrently with caffeine.
|
<combination hormonal contraceptives, effect, caffeine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The response to Factrel may be blunted by phenothiazines and dopamine antagonists which cause a rise in prolactin.
|
<Factrel, effect, phenothiazines>, <Factrel, effect, dopamine antagonists>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Diuretics: Patients on diuretics, especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with Lotensin.
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<diuretics, effect, Lotensin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The possibility of hypotensive effects with Lotensin can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with Lotensin.
|
<diuretic, advise, Lotensin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Potassium Supplements and Potassium-Sparing Diuretics Lotensin can attenuate potassium loss caused by thiazide diuretics.
|
<Potassium-Sparing Diuretics, effect, thiazide diuretics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.
|
<ACE inhibitors, mechanism, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If a diuretic is also used, the risk of lithium toxicity may be increased.
|
<diuretic, effect, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Benazepril, like other ACE inhibitors, has had less than additive effects with beta-adrenergic blockers, presumably because both drugs lower blood pressure by inhibiting parts of the renin-angiotensin system
|
<Benazepril, effect, beta-adrenergic blockers>, <ACE inhibitors, effect, beta-adrenergic blockers>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Geocillin (carbenicillin indanyl sodium) blood levels may be increased and prolonged by concurrent administration of probenecid.
|
<Geocillin, mechanism, probenecid>, <carbenicillin indanyl sodium, mechanism, probenecid>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
|
<sulfonylurea, effect, nonsteroidal anti-inflammatory agents>, <sulfonylurea, effect, salicylates>, <sulfonylurea, effect, sulfonamides>, <sulfonylurea, effect, chloramphenicol>, <sulfonylurea, effect, probenecid>, <sulfonylurea, effect, coumarins>, <sulfonylurea, effect, monoamine oxidase inhibitors>, <sulfonylurea, effect, beta adrenergic blocking agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution.
|
<barbiturates, effect, chlorpropamide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.
|
<miconazole, effect, hypoglycemic agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Aspirin: Concomitant administration of aspirin with valdecoxib may result in an increased risk of GI ulceration and complications compared to valdecoxib alone.
|
<aspirin, effect, valdecoxib>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
ACE-inhibitors:Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors.
|
<NSAIDs, effect, ACE-inhibitors>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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This interaction should be given consideration in patients taking BEXTRA concomitantly with ACE-inhibitors.
|
<BEXTRA, advise, ACE-inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.
|
<NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Anticonvulsants (Phenytoin): Steady state plasma exposure (AUC) of valdecoxib (40 mg BID for 12 days) was decreased by 27% when co-administered with multiple doses (300 mg QD for 12 days) of phenytoin (a CYP 3A4 inducer).
|
<valdecoxib, mechanism, phenytoin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients already stabilized on valdecoxib should be closely monitored for loss of symptom control with phenytoin coadministration.
|
<valdecoxib, advise, phenytoin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Coadministration with valdecoxib (40 mg BID for 7 days) resulted in a significant increase in dextromethorphan plasma levels suggesting that, at these doses, valdecoxib is a weak inhibitor of 2D6.
|
<valdecoxib, mechanism, dextromethorphan>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Even so dextromethorphan plasma concentrations in the presence of high doses of valdecoxib were almost 5-fold lower than those seen in CYP 2D6 poor metabolizers suggesting that dose adjustment is not necessary.
|
<dextromethorphan, mechanism, valdecoxib>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lithium: Valdecoxib 40 mg BID for 7 days produced significant decreases in lithium serum clearance (25%) and renal clearance (30%) with a 34% higher serum exposure compared to lithium alone.
|
<Valdecoxib, mechanism, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lithium serum concentrations should be monitored closely when initiating or changing therapy with BEXTRA in patients receiving lithium.
|
<BEXTRA, advise, lithium>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Valdecoxib caused a statistically significant increase in plasma exposures of R-warfarin and S-warfarin (12% and 15%, respectively), and in the pharmacodynamic effects (prothrombin time, measured as INR) of warfarin.
|
<Valdecoxib, mechanism, R-warfarin>, <Valdecoxib, mechanism, S-warfarin>, <Valdecoxib, effect, warfarin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Anticoagulant therapy should be monitored, particularly during the first few weeks, after initiating therapy with BEXTRA in patients receiving warfarin or similar agents.
|
<BEXTRA, advise, warfarin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant single dose administration of valdecoxib 20 mg with multiple doses of ketoconazole and fluconazole produced a significant increase in exposure of valdecoxib.
|
<valdecoxib, mechanism, ketoconazole>, <valdecoxib, mechanism, fluconazole>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Plasma exposure (AUC) to valdecoxib was increased 62% when coadministered with fluconazole and 38% when coadministered with ketoconazole.
|
<valdecoxib, mechanism, fluconazole>, <valdecoxib, mechanism, ketoconazole>
|
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