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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of valdecoxib (40 mg BID (day 1) and 40 mg QD (days 2-7)) with glyburide (10 mg glyburide BID) resulted in 21% increase in glyburide AUC0-12 and a 16% increase in glyburide Cmax leading to a 16% decrease in glucose AUC0-24.
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<valdecoxib, mechanism, glyburide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Because changes in glucose concentrations with valdecoxib coadministration were within the normal variability and individual glucose concentrations were above or near 70 mg/dL, dose adjustment for glyburide (5 mg QD and 10 mg BID) with valdecoxib coadministration (up to 40 mg QD) is not indicated.
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<glyburide, advise, valdecoxib>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration with valdecoxib increased exposure of omeprazole (AUC) by 46%.
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<valdecoxib, mechanism, omeprazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of valdecoxib and Ortho-Novum 1/35 increased the exposure of norethindrone and ethinyl estradiol by 20% and 34%, respectively.
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<valdecoxib, mechanism, Ortho-Novum>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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These increased exposures of norethindrone and ethinyl estradiol should be taken into consideration when selecting an oral contraceptive for women taking valdecoxib.
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<contraceptive, advise, valdecoxib>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Plasma exposure of diazepam (10 mg BID) was increased by 28% following administration of valdecoxib (40 mg BID) for 12 days, while plasma exposure of valdecoxib (40 mg BID) was not substantially increased following administration of diazepam (10 mg BID) for 12 days.
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<diazepam, mechanism, valdecoxib>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although the magnitude of changes in diazepam plasma exposure when coadministered with valdecoxib were not sufficient to warrant dosage adjustments, patients may experience enhanced sedative side effects caused by increased exposure of diazepam under this circumstance.
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<valdecoxib, effect, diazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Given the primary CNS effects of Clozapine, caution is advised in using it concomitantly with other CNS-active drugs or alcohol.
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<Clozapine, effect, alcohol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although it has not been established that there is an interaction between Clozapine and benzodiazepines or other psychotropics, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.
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<clozapine, advise, benzodiazepine>, <clozapine, advise, psychotropic drug>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Clozapine may potentiate the hypotensive effects of antihypertensive drugs and the anticholinergic effects of atropine-type drugs.
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<Clozapine, effect, antihypertensive drugs>, <Clozapine, effect, atropine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Phenytoin, nicotine, and rifampin may decrease Clozapine plasma levels, resulting in a decrease in effectiveness of a previously effective Clozapine dose.
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<Phenytoin, mechanism, Clozapine>, <nicotine, mechanism, Clozapine>, <rifampin, mechanism, Clozapine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cimetidine, caffeine, and erythromycin may increase plasma levels of Clozapine, potentially resulting in adverse effects.
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<Cimetidine, mechanism, Clozapine>, <caffeine, mechanism, Clozapine>, <erythromycin, mechanism, Clozapine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although concomitant use of Clozapine and carbamazepine is not recommended, it should be noted that discontinuation of concomitant carbamazepine administration may result in an increase in Clozapine plasma levels.
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<Clozapine, advise, carbamazepine>, <carbamazepine, mechanism, Clozapine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Paroxetine produced only minor changes in the levels of clozapine and its metabolites.
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<Paroxetine, mechanism, clozapine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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However, other published reports describe modest elevations (less than two-fold) of clozapine and metabolite concentrations when clozapine was taken with paroxetine, fluoxetine, and sertraline.
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<clozapine, mechanism, paroxetine>, <clozapine, mechanism, fluoxetine>, <clozapine, mechanism, sertraline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, such combined treatment should be approached with caution and patients should be monitored closely when Clozapine is combined with these drugs, particularly with fluvoxamine.
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<Clozapine, advise, fluvoxamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, co-administration of clozapine with other drugs that are metabolized by this isozyme, including antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (e.g., propafenone, flecainide and encainide), or that inhibit this enzyme (e.g., quinidine), should be approached with caution.
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<clozapine, advise, antidepressants>, <clozapine, advise, phenothiazines>, <clozapine, advise, carbamazepine>, <clozapine, advise, Type 1C antiarrhythmics>, <clozapine, advise, propafenone>, <clozapine, advise, flecainide>, <clozapine, advise, encainide>, <clozapine, advise, quinidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine.
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<quinolones, mechanism, caffeine>, <ciprofloxacin, mechanism, caffeine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
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<quinolones, effect, cyclosporine>, <ciprofloxacin, effect, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Glyburide: The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.
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<ciprofloxacin, effect, sulfonylurea>, <ciprofloxacin, effect, glyburide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Methotrexate Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate.
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<methotrexate, mechanism, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.
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<methotrexate, advise, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Multivalent Cation-Containing Products: Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired.
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<quinolone, mechanism, magnesium>, <quinolone, mechanism, aluminum>, <quinolone, mechanism, antacids>, <quinolone, mechanism, sucralfate>, <quinolone, mechanism, VIDEX>, <quinolone, mechanism, calcium>, <quinolone, mechanism, iron>, <quinolone, mechanism, zinc>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, aluminum>, <ciprofloxacin, mechanism, antacids>, <ciprofloxacin, mechanism, sucralfate>, <ciprofloxacin, mechanism, VIDEX>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, iron>, <ciprofloxacin, mechanism, zinc>, <ciprofloxacin, mechanism, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.
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<ciprofloxacin, advise, antacids>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Phenytoin: Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.
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<phenytoin, mechanism, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Probenecid: Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.
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<Probenecid, mechanism, ciprofloxacin>, <Probenecid, mechanism, ciprofloxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Theophylline: As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life.
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<quinolones, mechanism, theophylline>, <ciprofloxacin, mechanism, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Warfarin: Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives.
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<Quinolones, effect, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Bismuth: Bismuth subsalicylate, given concomitantly with enoxacin or 60 minutes following enoxacin administration, decreased enoxacin bioavailability by approximately 25%.
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<Bismuth subsalicylate, mechanism, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Thus, concomitant administration of enoxacin and bismuth subsalicylate should be avoided.
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<enoxacin, advise, bismuth subsalicylate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caffeine: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.
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<Enoxacin, mechanism, methylxanthines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In a multiple-dose study, enoxacin caused a dose-related increase in the mean elimination half-life of caffeine, thereby decreasing the clearance of caffeine by up to 80% and leading to a five-fold increase in the AUC and the half-life of caffeine.
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<enoxacin, mechanism, caffeine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Trough plasma enoxacin levels were also 20% higher when caffeine and enoxacin were administered concomitantly.
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<caffeine, mechanism, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caffeine-related adverse effects have occurred in patients consuming caffeine while on therapy with enoxacin.
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<caffeine, effect, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class.
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<cyclosporine, mechanism, quinolone class>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Digoxin: Enoxacin may raise serum digoxin levels in some individuals.
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<Enoxacin, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If signs and symptoms suggestive of digoxin toxicity occur when enoxacin and digoxin are given concomitantly, physicians are advised to obtain serum digoxin levels and adjust digoxin doses appropriately.
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<enoxacin, effect, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Non-steroidal anti-inflammatory agents: Seizures have been reported in patients taking enoxacin concomitantly with the nonsteroidal anti-inflammatory drug fenbufen.
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<enoxacin, effect, fenbufen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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or with multivitamins containing zinc may substantially interfere with drug absorption and result in insufficient plasma and tissue quinolone concentrations.
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<zinc, mechanism, quinolone>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Antacids containing aluminum hydroxide and magnesium hydroxide reduce the oral absorption of enoxacin by 75%.
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<aluminum hydroxide, mechanism, enoxacin>, <magnesium hydroxide, mechanism, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The oral bioavailability of enoxacin is reduced by 60% with coadministration of ranitidine.
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<enoxacin, mechanism, ranitidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Theophylline: Enoxacin is a potent inhibitor of the cytochrome P-450 isozymes responsible for the metabolism of methylxanthines.
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<Enoxacin, mechanism, methylxanthines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Enoxacin interferes with the metabolism of theophylline resulting in a 42% to 74% dose-related decrease in theophylline clearance and a subsequent 260% to 350% increase in serum theophylline levels.
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<Enoxacin, mechanism, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Theophylline-related adverse effects have occurred in patients when theophylline and enoxacin were coadministered.
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<theophylline, effect, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Warfarin: Quinolones, including enoxacin, decrease the clearance of R-warfarin, the less active isomer of racemic warfarin.
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<Quinolones, mechanism, R-warfarin>, <enoxacin, mechanism, R-warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Nevertheless, the prothrombin time or other suitable coagulation test should be monitored when warfarin or its derivatives and enoxacin are given concomitantly.
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<warfarin, advise, enoxacin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Rifampin: Coadministration of rifampin and MEPRON Suspension results in a significant decrease in average steady- state plasma atovaquone concentrations.
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<rifampin, mechanism, MEPRON>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Alternatives to rifampin should be considered during the course of PCP treatment with MEPRON.
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<rifampin, advise, MEPRON>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Products containing calcium and other multivalent cations (such as aluminum, magnesium, iron) are likely to interfere with absorption of Ibandronate.
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<calcium, mechanism, Ibandronate>, <aluminum, mechanism, Ibandronate>, <magnesium, mechanism, Ibandronate>, <iron, mechanism, Ibandronate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Ibandronate should be taken at least 60 minutes before any oral medications containing multivalent cations (including antacids, supplements or vitamins).
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<Ibandronate, advise, antacids>, <Ibandronate, advise, vitamins>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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However, since aspirin, NSAIDs, and bisphosphonates are all associated with gastrointestinal irritation, caution should be exercised in the concomitant use of aspirin or NSAIDs with Ibandronate.
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<aspirin, advise, Ibandronate>, <NSAIDs, advise, Ibandronate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Total body clearance of Simulect was reduced by an average 22% and 51% when azathioprine and mycophenolate mofetil, respectively, were added to a regimen consisting of cyclosporine, USP (MODIFIED) and corticosteroids.
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<Simulect, mechanism, azathioprine>, <Simulect, mechanism, mycophenolate mofetil>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.
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<benzodiazepines, effect, psychotropic medications>, <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistaminics>, <benzodiazepines, effect, ethanol>, <alprazolam, effect, psychotropic medications>, <alprazolam, effect, anticonvulsants>, <alprazolam, effect, antihistaminics>, <alprazolam, effect, ethanol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of alprazolam tablets in doses up to 4 mg/day.
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<imipramine, mechanism, alprazolam>, <desipramine, mechanism, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs Demonstrated to be CYP 3A Inhibitors of Possible Clinical Significance on the Basis of Clinical Studies Involving Alprazolam (caution is recommended during coadministration with alprazolam): Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased half-life by 17%, and decreased measured psychomotor performance.
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<fluoxetine, mechanism, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of propoxyphene decreased the maximum plasma concentration of alprazolam by 6%, decreased clearance by 38%, and increased half-life by 58%.
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<propoxyphene, mechanism, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Coadministration of oral contraceptives increased the maximum plasma concentration of alprazolam by 18%, decreased clearance by 22%, and increased half-life by 29%.
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<contraceptives, mechanism, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs and other substances demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to alprazolam or on the basis of in vitro studies with alprazolam or other benzodiazepines (caution is recommended during coadministration with alprazolam): Available data from clinical studies of benzodiazepines other than alprazolam suggest a possible drug interaction with alprazolam for the following: diltiazem, isoniazid, macrolide antibiotics such as erythromycin and clarithromycin, and grapefruit juice.
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<alprazolam, int, diltiazem>, <alprazolam, int, isoniazid>, <alprazolam, int, macrolide antibiotics>, <alprazolam, int, erythromycin>, <alprazolam, int, clarithromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Data from in vitro studies of alprazolam suggest a possible drug interaction with alprazolam for the following: sertraline and paroxetine.
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<alprazolam, int, sertraline>, <alprazolam, int, paroxetine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Data from in vitro studies of benzodiazepines other than alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine.
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<benzodiazepines, int, ergotamine>, <benzodiazepines, int, cyclosporine>, <benzodiazepines, int, amiodarone>, <benzodiazepines, int, nicardipine>, <benzodiazepines, int, nifedipine>, <alprazolam, int, ergotamine>, <alprazolam, int, cyclosporine>, <alprazolam, int, amiodarone>, <alprazolam, int, nicardipine>, <alprazolam, int, nifedipine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Interactions with Other CNS Agents: Concurrent use of Levo-Dromoran with all central nervous system depressants (eg, alcohol, sedatives, hypnotics, other opioids, general anesthetics, barbiturates, tricyclic antidepressants, phenothiazines, tranquilizers, skeletal muscle relaxants and antihistamines) may result in additive central nervous system depressant effects.
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<Levo-Dromoran, effect, central nervous system depressants>, <Levo-Dromoran, effect, alcohol>, <Levo-Dromoran, effect, sedatives>, <Levo-Dromoran, effect, hypnotics>, <Levo-Dromoran, effect, opioids>, <Levo-Dromoran, effect, anesthetics>, <Levo-Dromoran, effect, barbiturates>, <Levo-Dromoran, effect, tricyclic antidepressants>, <Levo-Dromoran, effect, phenothiazines>, <Levo-Dromoran, effect, tranquilizers>, <Levo-Dromoran, effect, skeletal muscle relaxants>, <Levo-Dromoran, effect, antihistamines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although no interaction between MAO inhibitors and Levo-Dromoran has been observed, it is not recommended for use with MAO inhibitors.
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<Levo-Dromoran, advise, MAO inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Interactions with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (eg, pentazocine, nalbuphine, butorphanol, dezocine and buprenorphine) should NOT be administered to a patient who has received or is receiving a course of therapy with a pure agonist opioid analgesic such as Levo-Dromoran.
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<Agonist/antagonist analgesics, advise, Levo-Dromoran>, <pentazocine, advise, Levo-Dromoran>, <nalbuphine, advise, Levo-Dromoran>, <butorphanol, advise, Levo-Dromoran>, <dezocine, advise, Levo-Dromoran>, <buprenorphine, advise, Levo-Dromoran>, <pure agonist opioid analgesic, advise, Levo-Dromoran>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Amitriptyline: Concurrent administration of 25 mg or 100 mg cinacalcet with 50 mg amitriptyline increased amitriptyline exposure and nortriptyline (active metabolite) exposure by approximately 20% in CYP2D6 extensive metabolizers.
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<cinacalcet, mechanism, amitriptyline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-administration of ketoconazole, a strong inhibitor of CYP3A4, increased cinacalcet exposure following a single 90 mg dose of Sensipar by 2.3 fold.
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<ketoconazole, mechanism, cinacalcet>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Dose adjustment of Sensipar may be required and PTH and serum calcium concentrations should be closely monitored if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, erythromycin, itraconazole;
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<Sensipar, advise, ketoconazole>, <Sensipar, advise, erythromycin>, <Sensipar, advise, itraconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-treatment with the potent CYP3A4 inhibitor ketoconazole increases erlotinib AUC by 2/3.
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<ketoconazole, mechanism, erlotinib>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caution should be used when administering or taking TARCEVA with ketoconazole and other strong CYP3A4 inhibitors such as, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), and voriconazole .
|
<TARCEVA, advise, ketoconazole>, <TARCEVA, advise, atazanavir>, <TARCEVA, advise, clarithromycin>, <TARCEVA, advise, indinavir>, <TARCEVA, advise, itraconazole>, <TARCEVA, advise, nefazodone>, <TARCEVA, advise, nelfinavir>, <TARCEVA, advise, ritonavir>, <TARCEVA, advise, saquinavir>, <TARCEVA, advise, telithromycin>, <TARCEVA, advise, troleandomycin>, <TARCEVA, advise, TAO>, <TARCEVA, advise, voriconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Pre-treatment with the CYP3A4 inducer rifampicin decreased erlotinib AUC by about 2/3.
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<rifampicin, mechanism, erlotinib>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If the TARCEVA dose is adjusted upward, the dose will need to be reduced upon discontinuation of rifampicin or other inducers.
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<TARCEVA, advise, rifampicin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Other depressasnts such as alcohol, barbiturates, and MAOIs may enhance CNS depression when administered with ethchlorvynol.
|
<alcohol, effect, ethchlorvynol>, <barbiturates, effect, ethchlorvynol>, <MAOIs, effect, ethchlorvynol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In the first study, concomitant administration of 0.2 mg cerivastatin sodium and 12 g cholestyramine resulted in decreases of more than 22% for AUC and 40% for Cmax when compared to dosing cerivastatin sodium alone.
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<cerivastatin sodium, mechanism, cholestyramine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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However, in the second study, administration of 12 g cholestyramine 1 hour before the evening meal and 0.3 mg cerivastatin sodium approximately 4 hours after the same evening meal resulted in a decrease in the cerivastatin AUC of less than 8%, and a decrease in Cmax of about 30% when compared to dosing cerivastatin sodium alone.
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<cholestyramine, mechanism, cerivastatin sodium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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ERYTHROMYCIN: In hypercholesterolemic patients, steady-state cerivastatin AUC and Cmax increased approximately 50% and 24% respectively after 10 days with co-administration of erythromycin, a known inhibitor of cytochrome P450 3A4.
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<cerivastatin, mechanism, erythromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Allopurinol: The AUC of didanosine was increased about 4-fold when allopurinol at 300 mg/day was coadministered with a single 200-mg dose of VIDEX to two patients with renal impairment (CLcr=15 and 18 mL/min).
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<allopurinol, mechanism, VIDEX>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Antacids: Concomitant administration of antacids containing magnesium or aluminum with VIDEX Chewable/Dispersible Buffered Tablets or Pediatric Powder for Oral Solution may potentiate adverse events associated with the antacid components.
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<antacids, effect, VIDEX>, <magnesium, effect, VIDEX>, <aluminum, effect, VIDEX>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Drugs Whose Absorption Can Be Affected by the Level of Acidity in the Stomach: Drugs such as ketoconazole and itraconazole should be administered at least 2 hours prior to dosing with VIDEX.
|
<ketoconazole, advise, VIDEX>, <itraconazole, advise, VIDEX>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Ganciclovir: Administration of VIDEX 2 hours prior to or concurrent with oral ganciclovir was associated with a 111 (114)% increase in the steady-state AUC of didanosine (n = 12).
|
<VIDEX, mechanism, ganciclovir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
A 21 (17)% decrease in the steady-state AUC of ganciclovir was observed when VIDEX was administered 2 hours prior to ganciclovir, but not when the two drugs were administered simultaneously (n = 12).
|
<VIDEX, mechanism, ganciclovir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Quinolone Antibiotics: VIDEX should be administered at least 2 hours after or 6 hours before dosing with ciprofloxacin because plasma concentrations of ciprofloxacin are decreased when administered with antacids containing magnesium, calcium, or aluminum.
|
<VIDEX, advise, ciprofloxacin>, <ciprofloxacin, mechanism, magnesium>, <ciprofloxacin, mechanism, calcium>, <ciprofloxacin, mechanism, aluminum>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In eight HIV-infected patients, the steady-state AUC of ciprofloxacin was decreased an average of 26% (95% CI = 14%, 37%) when ciprofloxacin was administered 2 hours prior to a marketed chewable/dispersible tablet formulation of VIDEX.
|
<ciprofloxacin, mechanism, VIDEX>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The AUC of ciprofloxacin was decreased an average of 15-fold in 12 healthy subjects given ciprofloxacin and didanosine-placebo tablets concurrently.
|
<ciprofloxacin, mechanism, didanosine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In a single subject given one dose of ciprofloxacin 2 hours after a dose of didanosine-placebo tablets, a greater than 50% reduction in the AUC of ciprofloxacin was observed.
|
<ciprofloxacin, mechanism, didanosine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Plasma concentrations of quinolone antibiotics are decreased when administered with antacids containing magnesium, calcium, or aluminum.
|
<quinolone antibiotics, mechanism, magnesium>, <quinolone antibiotics, mechanism, calcium>, <quinolone antibiotics, mechanism, aluminum>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Interactions with Other Antiretroviral Drugs: Significant decreases in the AUC of delavirdine (20%) and indinavir (84%) occurred following simultaneous administration of these agents with VIDEX.
|
<delavirdine, mechanism, VIDEX>, <indinavir, mechanism, VIDEX>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
To avoid this interaction, delavirdine or indinavir should be given 1 hour prior to dosing with VIDEX.
|
<delavirdine, advise, VIDEX>, <indinavir, advise, VIDEX>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.
|
<SSRI, effect, TCA>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Nevertheless, caution is indicated in the coadministration of TCAs with any of the SSRIs and also in switching from one class to the other.
|
<TCAs, advise, SSRIs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Hyperpyrexia has been reported when amitriptyline HCl is administered with anticholinergic agents or with neuroleptic drugs, particularly during hot weather.
|
<amitriptyline HCl, effect, anticholinergic>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs.
|
<tricyclic antidepressants, effect, anticholinergic>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs.
|
<Cimetidine, mechanism, tricyclic antidepressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine.
|
<tricyclic antidepressants, effect, cimetidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Increases in plasma levels of tricyclic antidepressants, and in the frequency and severity of side effects, particularly anticholinergic, have been reported when cimetidine was added to the drug regimen.
|
<tricyclic antidepressants, mechanism, cimetidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Discontinuation of cimetidine in well-controlled patients receiving tricyclic antidepressants and cimetidine may decrease the plasma levels and efficacy of the antidepressants.
|
<tricyclic antidepressants, mechanism, cimetidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Transient delirium has been reported in patients who were treated with one gram of ethchlorvynol and 75 - 150 mg of amitriptyline HCl.
|
<ethchlorvynol, effect, amitriptyline HCl>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac.
|
<beta-blockers, effect, Tiazac>, <digitalis, effect, Tiazac>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%.
|
<diltiazem hydrochloride, mechanism, propranolol>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In vitro, propranolol appears to be displaced from its binding sites by diltiazem.
|
<propranolol, mechanism, diltiazem>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg.
|
<cimetidine, mechanism, diltiazem>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The effect may be mediated by cimetidines known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem.
|
<cimetidine, mechanism, diltiazem>
|
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