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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time.
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<INDOCIN, advise, anticoagulant>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN.
|
<anticoagulants, effect, INDOCIN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.
|
<INDOCIN, advise, anticoagulants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased.
|
<INDOCIN, mechanism, probenecid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caution should be used if INDOCIN is administered simultaneously with methotrexate.
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<INDOCIN, advise, methotrexate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.
|
<INDOCIN, mechanism, methotrexate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.
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<non-steroidal anti-inflammatory drugs, effect, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.
|
<NSAIDs, advise, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Capsules INDOCIN 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations.
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<INDOCIN, mechanism, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity.
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<INDOCIN, advise, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.
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<INDOCIN, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.
|
<INDOCIN, advise, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics.
|
<INDOCIN, effect, loop diuretics>, <INDOCIN, effect, potassium-sparing diuretics>, <INDOCIN, effect, thiazide diuretics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers.
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<triamterene, effect, INDOCIN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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INDOCIN and triamterene should not be administered together.
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<INDOCIN, advise, triamterene>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.
|
<INDOCIN, effect, potassium-sparing diuretics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.
|
<diuretics, effect, INDOCIN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported.
|
<beta-adrenoceptor blocking agents, effect, non-steroidal antiinflammatory drugs>, <beta-adrenoceptor blocking agents, effect, INDOCIN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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INDOCIN can reduce the antihypertensive effects of captopril and losartan.
|
<INDOCIN, effect, captopril>, <INDOCIN, effect, losartan>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole (see CLINICAL PHARMACOLOGY Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections).
|
<tamoxifen, advise, anastrozole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-administration of anastrozole and tamoxifen resulted in a reduction of anastrozole plasma levels by 27% compared with those achieved with anastrozole alone.
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<anastrozole, mechanism, tamoxifen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Estrogen-containing therapies should not be used with ARIMIDEX as they may diminish its pharmacologic action.
|
<Estrogen, advise, ARIMIDEX>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.
|
<Chlorthalidone, effect, antihypertensive drugs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.
|
<Chlorthalidone, effect, tubocurarine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine.
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<Chlorthalidone, effect, norepinephrine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In another drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.
|
<ciclesonide, mechanism, ketoconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, ketoconazole should be administered with caution with intranasal ciclesonide.
|
<ketoconazole, advise, ciclesonide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If you are also using a steroid inhaler, take bitolterol first and then wait about 15 minutes before using the steroid inhaler.
|
<steroid, advise, bitolterol>, <bitolterol, advise, steroid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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This allows bitolterol to open air passages, increasing the effectiveness of the steroid.
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<bitolterol, effect, steroid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Hypotension Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril.
|
<diuretics, effect, captopril>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril (captopril tablets, USP) or initiating therapy with small doses (6.25 or 12.5 mg).
|
<captopril, effect, diuretic>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril.
|
<nitroglycerin, advise, captopril>, <nitrates, advise, captopril>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Agents Causing Renin Release Captopril's effect will be augmented by antihypertensive agents that cause renin release.
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<Captopril, effect, antihypertensive agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Beta-adrenergic blocking drugs add some further antihypertensive effect to captopril, but the overall response is less than additive.
|
<Beta-adrenergic blocking drugs, effect, captopril>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Inhibitors Of Endogenous Prostaglandin Synthesis It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension.
|
<indomethacin, effect, captopril>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy.
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<lithium, effect, ACE inhibitor>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If a diuretic is also used, it may increase the risk of lithium toxicity.
|
<diuretic, effect, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;
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<TRACRIUM, effect, enflurane>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;isoflurane;halothane;certain antibiotics, especially the aminoglycosides and polymyxins;lithium;magnesium salts;procainamide;and quinidine.
|
<TRACRIUM, effect, enflurane>, <TRACRIUM, effect, isoflurane>, <TRACRIUM, effect, halothane>, <TRACRIUM, effect, antibiotics>, <TRACRIUM, effect, aminoglycosides>, <TRACRIUM, effect, polymyxins>, <TRACRIUM, effect, lithium>, <TRACRIUM, effect, magnesium>, <TRACRIUM, effect, procainamide>, <TRACRIUM, effect, quinidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The prior administration of succinylcholine does not enhance the duration, but quickens the onset and may increase the depth, of neuromuscular block induced by TRACRIUM.
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<succinylcholine, effect, TRACRIUM>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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TRACRIUM should not be administered until a patient has recovered from succinylcholine-induced neuromuscular block.
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<TRACRIUM, advise, succinylcholine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Potential drug interactions for doxylamine include, increased sedation if doxylamine is combined with other CNS depressant drugs.
|
<doxylamine, effect, CNS depressant drugs>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.
|
<Antihistamines, effect, heparin>, <Antihistamines, effect, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Doxylamine may enhance the effects of epinephrine.
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<Doxylamine, effect, epinephrine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.
|
<NSAIDs, effect, ACE inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Concomitant administration of naproxen and aspirin is not recommended because naproxen is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.
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<naproxen, advise, aspirin>, <naproxen, advise, aspirin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.
|
<Naproxen, effect, propranolol>, <Naproxen, effect, beta-blockers>, <NSAIDs, effect, propranolol>, <NSAIDs, effect, beta-blockers>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly.
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<Probenecid, mechanism, naproxen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caution should be used if naproxen is administered concomitantly with methotrexate.
|
<naproxen, advise, methotrexate>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Naproxen, naproxen sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.
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<Naproxen, mechanism, methotrexate>, <naproxen sodium, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.
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<CEFOTAN, effect, aminoglycoside>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Colchicine is inhibited by acidifying agents.
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<Colchicine, mechanism, acidifying agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The action of colchicine is potentiated by alkalinizing agents.
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<colchicine, mechanism, alkalinizing agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Colchicine may increase sensitivity to the CNS depressants.
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<Colchicine, effect, CNS depressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Response to sympathomimetic agents may be enhanced by colchicine.
|
<sympathomimetic agents, effect, colchicine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anagrelide alone had no effect on platelet aggregation, but did slightly enhance the inhibition of platelet aggregation by aspirin.
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<Anagrelide, effect, aspirin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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It is known that CYP1A2 is inhibited by several medicinal products, including fluvoxamine, and such medicinal products could theoretically adversely influence the clearance of anagrelide.
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<fluvoxamine, mechanism, anagrelide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anagrelide demonstrates some limited inhibitory activity towards CYP1A2 which may present a theoretical potential for interaction with other coadministered medicinal products sharing that clearance mechanism e.g. theophylline.
|
<Anagrelide, mechanism, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.
|
<milrinone, effect, anagrelide>, <enoximone, effect, anagrelide>, <amrinone, effect, anagrelide>, <olprinone, effect, anagrelide>, <cilostazol, effect, anagrelide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption.
|
<sucralfate, mechanism, anagrelide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.
|
<FLUOTHANE, effect, non-depolarising muscle relaxant>, <FLUOTHANE, effect, aminoglycosides>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.
|
<FLUOTHANE, effect, tubocurarine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated.
|
<adrenaline, advise, FLUOTHANE>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects
|
<Accutane, effect, vitamin A>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines
|
<Accutane, advise, tetracyclines>, <Accutane, effect, tetracyclines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations (minipills that do not contain an estrogen) may be an inadequate method of contraception during Accutane therapy.
|
<progesterone, effect, Accutane>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents.
|
<reserpine, effect, beta-blocking>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine.
|
<beta-blockers, advise, clonidine>, <beta-blocker, advise, clonidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function.
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<calcium antagonists, advise, beta-adrenergic blocking agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.
|
<beta-adrenergic blocking agents, effect, calcium antagonist>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks.
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<beta-blockers, effect, epinephrine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The potential for increased sedation when guanfacine is given with other CNS-depressant drug should be appreciated.
|
<guanfacine, effect, CNS-depressant drug>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The administration of guanfacine concomitantly with known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration.
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<guanfacine, mechanism, phenobarbital>, <guanfacine, mechanism, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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TCAs decrease the hypotensive effect of guanfacine.
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<TCAs, effect, guanfacine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Noncardioselective beta-blockers (nadolol,porpranolol,timolol) may exacerbate rebound hypertension when guanfacine is withdrawn.
|
<Noncardioselective beta-blockers, effect, guanfacine>, <nadolol, effect, guanfacine>, <timolol, effect, guanfacine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.
|
<SSRI, int, TCA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Nevertheless, caution is indicated in the co-administration of T.A. with any of the SSRIs and also in switching from one class to the other.
|
<T.A., advise, SSRIs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive.
|
<desipramine hydrochloride, effect, psychotropic agents>, <desipramine hydrochloride, effect, tranquilizers>, <desipramine hydrochloride, effect, sedative>, <desipramine hydrochloride, effect, hypnotics>, <desipramine, effect, benzodiazepines>, <desipramine, effect, chlordiazepoxide>, <desipramine, effect, diazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.
|
<major tranquilizers, effect, desipramine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma levels of the tricyclic antidepressants.
|
<cimetidine, mechanism, tricyclic antidepressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant 6.
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<tricyclic antidepressants, mechanism, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There have been greater than two-fold increases of previously stable plasma levels of tricyclic antidepressants when fluoxetine has been administered in combination with these agents.
|
<tricyclic antidepressants, mechanism, fluoxetine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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however, 150 mg of ranitidine q12h for 3 days increased the ceftibuten C max by 23% and ceftibuten AUC by 16%.
|
<ranitidine, mechanism, ceftibuten>, <ranitidine, mechanism, ceftibuten>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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FLEXERIL may have life-threatening interactions with MAO inhibitors.
|
<FLEXERIL, int, MAO inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.
|
<FLEXERIL, effect, alcohol>, <FLEXERIL, effect, barbiturates>, <FLEXERIL, effect, CNS depressants>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.
|
<Tricyclic antidepressants, effect, guanethidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol
|
<Tricyclic antidepressants, effect, tramadol>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Urinary acidifying agents These agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.
|
<ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Adrenergic blockers Adrenergic blockers are inhibited by amphetamines.
|
<Adrenergic blockers, effect, amphetamines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Antidepressants, tricyclic Amphetamines may enhance the activity of tricyclic antidepressants or sympathomimetic agents;
|
<Amphetamines, effect, tricyclic antidepressants>, <Amphetamines, effect, sympathomimetic agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;
|
<d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
MAO inhibitors MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.
|
<MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.
|
<Amphetamines, effect, antihistamines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.
|
<Amphetamines, effect, antihypertensives>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines and can be used to treat amphetamine poisoning.
|
<Chlorpromazine, effect, amphetamines>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.
|
<Amphetamines, mechanism, ethosuximide>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Haloperidol: Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines.
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<Haloperidol, effect, amphetamines>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Lithium carbonate: The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate.
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<amphetamines, effect, lithium carbonate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Meperidine: Amphetamines potentiate the analgesic effect of meperidine.
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<Amphetamines, effect, meperidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Methenamine therapy Urinary excretion of amphetamines is increased, and efficacy is reduced by acidifying agents used in methenamine therapy.
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<amphetamines, mechanism, methenamine>
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