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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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For example, since cholestyramine may reduce the gastrointestinal absorption of both the oral anticoagulants and vitamin K, the net effects are unpredictable.
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<cholestyramine, mechanism, anticoagulants>, <cholestyramine, mechanism, vitamin K>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Chloral hydrate may cause an increased prothrombin response by displacing the anticoagulant from protein binding sites or a diminished prothrombin response through increased metabolism of the unbound drug by hepatic enzyme induction, thus leading to inter-patient variation in ultimate prothrombin effect.
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<Chloral hydrate, mechanism, anticoagulant>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;
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<anticoagulant, effect, adrenocortical steroids>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs that have been reported to diminish oral anticoagulant response, ie, decreased prothrom-bin time response, in man significantly include: adrenocortical steroids;alcohol*;antacids;antihistamines;barbiturates;carbamazepine;chloral hydrate*;chlordiazepoxide;cholestyramine;diet high in vitamin K;diuretics*;ethchlorvynol;glutethimide;griseofulvin;haloperidol;meprobamate;oral contraceptives;paraldehyde;primidone;ranitidine*;rifampin;unreliable prothrombin time determinations;vitamin C;warfarin sodium under-dosage.
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<anticoagulant, effect, adrenocortical steroids>, <anticoagulant, effect, alcohol>, <anticoagulant, effect, antacids>, <anticoagulant, effect, antihistamines>, <anticoagulant, effect, barbiturates>, <anticoagulant, effect, carbamazepine>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlordiazepoxide>, <anticoagulant, effect, cholestyramine>, <anticoagulant, effect, vitamin K>, <anticoagulant, effect, diuretics>, <anticoagulant, effect, ethchlorvynol>, <anticoagulant, effect, glutethimide>, <anticoagulant, effect, griseofulvin>, <anticoagulant, effect, haloperidol>, <anticoagulant, effect, meprobamate>, <anticoagulant, effect, contraceptives>, <anticoagulant, effect, paraldehyde>, <anticoagulant, effect, primidone>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, rifampin>, <anticoagulant, effect, vitamin C>, <anticoagulant, effect, warfarin sodium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;
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<anticoagulant, effect, alcohol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs that reportedly may increase oral anticoagulant response, ie, increased prothrombin response, in man include:alcohol*;allopurinol;aminosalicylic acid;amiodarone;anabolic steroids;antibiotics;bromelains;chloral hydrate*;chlorpropamide;chymotrypsin;cimetidine;cinchophen;clofibrate;dextran;dextrothyroxine;diazoxide;dietary deficiencies;diflunisal;disulfiram;drugs affecting blood elements;ethacrynic acid;fenoprofen;glucagon;hepatotoxic drugs;ibuprofen;indomethacin;influenza virus vaccine;inhalation anesthetics;mefenamic acid;methyldopa;methylphenidate;metronidazole;miconazole;monoamine oxidase inhibitors;nalidixic acid;naproxen;oxolinic acid;oxyphenbutazone;pentoxifylline;phenylbutazone;phenyramidol;phenytoin;prolonged hot weather;prolonged narcotics;pyrazolones;quinidine;quinine;ranitidine*;salicylates;sulfinpyrazone;sulfonamides, long acting;sulindac;thyroid drugs;tolbutamide;triclofos sodium;trimethoprim/sulfamethoxazole;unreliable prothrombin time determinations;warfarin sodium overdosage.
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<anticoagulant, effect, alcohol>, <anticoagulant, effect, allopurinol>, <anticoagulant, effect, aminosalicylic acid>, <anticoagulant, effect, amiodarone>, <anticoagulant, effect, anabolic steroids>, <anticoagulant, effect, antibiotics>, <anticoagulant, effect, bromelains>, <anticoagulant, effect, chloral hydrate>, <anticoagulant, effect, chlorpropamide>, <anticoagulant, effect, chymotrypsin>, <anticoagulant, effect, cimetidine>, <anticoagulant, effect, cinchophen>, <anticoagulant, effect, clofibrate>, <anticoagulant, effect, dextran>, <anticoagulant, effect, dextrothyroxine>, <anticoagulant, effect, diazoxide>, <anticoagulant, effect, diflunisal>, <anticoagulant, effect, disulfiram>, <anticoagulant, effect, ethacrynic acid>, <anticoagulant, effect, fenoprofen>, <anticoagulant, effect, glucagon>, <anticoagulant, effect, ibuprofen>, <anticoagulant, effect, indomethacin>, <anticoagulant, effect, influenza virus vaccine>, <anticoagulant, effect, anesthetics>, <anticoagulant, effect, mefenamic acid>, <anticoagulant, effect, methyldopa>, <anticoagulant, effect, methylphenidate>, <anticoagulant, effect, metronidazole>, <anticoagulant, effect, miconazole>, <anticoagulant, effect, monoamine oxidase inhibitors>, <anticoagulant, effect, nalidixic acid>, <anticoagulant, effect, naproxen>, <anticoagulant, effect, oxolinic acid>, <anticoagulant, effect, oxyphenbutazone>, <anticoagulant, effect, pentoxifylline>, <anticoagulant, effect, phenylbutazone>, <anticoagulant, effect, phenyramidol>, <anticoagulant, effect, phenytoin>, <anticoagulant, effect, prolonged narcotics>, <anticoagulant, effect, pyrazolones>, <anticoagulant, effect, quinidine>, <anticoagulant, effect, quinine>, <anticoagulant, effect, ranitidine>, <anticoagulant, effect, salicylates>, <anticoagulant, effect, sulfinpyrazone>, <anticoagulant, effect, sulfonamides>, <anticoagulant, effect, sulindac>, <anticoagulant, effect, thyroid drugs>, <anticoagulant, effect, tolbutamide>, <anticoagulant, effect, triclofos sodium>, <anticoagulant, effect, trimethoprim>, <anticoagulant, effect, sulfamethoxazole>, <anticoagulant, effect, warfarin sodium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Oral anticoagulants may potentiate the hypoglycemic action of hypoglycemic agents, eg, tolbutamide and chlorpropamide, by inhibiting their metabolism in the liver.
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<anticoagulants, mechanism, hypoglycemic agents>, <anticoagulants, mechanism, tolbutamide>, <anticoagulants, mechanism, chlorpropamide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Because oral anticoagulants may interfere with the hepatic metabolism of phenytoin, toxic levels of the anticonvulsant may occur when an oral anticoagulant and phenytoin are administered concurrently.
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<anticoagulants, mechanism, phenytoin>, <anticoagulant, mechanism, phenytoin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Drugs that reduce the number of blood platelets by causing bone marrow depression (such as antineoplastic agents) or drugs which inhibit platelet function (eg, aspirin and other non-steroidal anti-inflammatory drugs, dipyridamole, hydrochloroquine, clofibrate, dextran) may increase the bleeding tendency produced by anticoagulants without altering prothrombin time determinations.
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<antineoplastic agents, effect, anticoagulants>, <aspirin, effect, anticoagulants>, <non-steroidal anti-inflammatory drugs, effect, anticoagulants>, <dipyridamole, effect, anticoagulants>, <hydrochloroquine, effect, anticoagulants>, <clofibrate, effect, anticoagulants>, <dextran, effect, anticoagulants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The beneficial effects on arterial thrombus formation from combined therapy with antiplatelet and anticoagulant medication must be weighed against an increased risk of inducing hemorrhage.
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<antiplatelet medication, advise, anticoagulant medication>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Co-administration of naltrexone with Acamprosate produced a 25% increase in AUC and a 33% increase in the Cmax of acamprosate.
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<naltrexone, mechanism, Acamprosate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients taking Acamprosate concomitantly with antidepressants more commonly reported both weight gain and weight loss, compared with patients taking either medication alone.
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<Acamprosate, effect, antidepressants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.
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<vasopressors, advise, monoamine oxidase (MAO) inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Epinephrine should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.
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<Epinephrine, advise, sympathomimetic drugs>, <Epinephrine, advise, isoproterenol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia..
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<epinephrine, effect, cyclopropane>, <epinephrine, effect, halogenated hydrocarbon general anesthetics>, <epinephrine, effect, halothane>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Epinephrine also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.
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<Epinephrine, advise, digitalis>, <Epinephrine, advise, glycosides>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.
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<Diuretic agents, effect, epinephrine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Epinephrine may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.
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<Epinephrine, effect, guanethidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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CANCIDAS reduced the blood AUC0-12 of tacrolimus by approximately 20%, peak blood concentration (Cmax) by 16%, and 12-hour blood concentration (C12hr) by 26% in healthy subjects when tacrolimus (2 doses of 0.1 mg/kg 12 hours apart) was administered on the 10th day of CANCIDAS 70 mg daily, as compared to results from a control period in which tacrolimus was administered alone.
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<CANCIDAS, mechanism, tacrolimus>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In two clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin by approximately 35%.
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<cyclosporine, mechanism, caspofungin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There were transient increases in liver ALT and AST when CANCIDAS and cyclosporine were co-administered.
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<CANCIDAS, effect, cyclosporine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A drug-drug interaction study with rifampin in healthy volunteers has shown a 30% decrease in caspofungin trough concentrations.
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<rifampin, mechanism, caspofungin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients on rifampin should receive 70 mg of CANCIDAS daily.
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<rifampin, advise, CANCIDAS>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In addition, results from regression analyses of patient pharmacokinetic data suggest that co-administration of other inducers of drug clearance (efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine) with CANCIDAS may result in clinically meaningful reductions in caspofungin concentrations.
|
<efavirenz, mechanism, CANCIDAS>, <nevirapine, mechanism, CANCIDAS>, <phenytoin, mechanism, CANCIDAS>, <dexamethasone, mechanism, CANCIDAS>, <carbamazepine, mechanism, CANCIDAS>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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When CANCIDAS is co-administered with inducers of drug clearance, such as efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine, use of a daily dose of 70 mg of CANCIDAS should be considered
|
<CANCIDAS, advise, efavirenz>, <CANCIDAS, advise, nevirapine>, <CANCIDAS, advise, phenytoin>, <CANCIDAS, advise, dexamethasone>, <CANCIDAS, advise, carbamazepine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Beta-adrenergic blocking agents should be withdrawn at least 48 hours before conducting an arbutamine-mediated stress test.
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<Beta-adrenergic blocking agents, advise, arbutamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
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<cephalosporins, effect, aminoglycoside antibiotics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.
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<Corticotropin, effect, diuretic>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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It is possible that the cardiovascular action of other calcium channel blockers could be enhanced by the addition of Nimotop .
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<calcium channel blockers, effect, Nimotop>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In Europe, Nimotop was observed to occasionally intensify the effect of antihypertensive compounds taken concomitantly by patients suffering from hypertension;
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<Nimotop, effect, antihypertensive compounds>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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A study in eight healthy volunteers has shown a 50% increase in mean peak nimodipine plasma concentrations and a 90% increase in mean area under the curve, after a one week course of cimetidine at 1,000 mg/day and nimodipine at 90 mg/day.
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<cimetidine, mechanism, nimodipine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tablets: The benzodiazepines, including lorazepam, produce CNS-depressant effects when administered with such medications as barbiturates or alcohol.
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<benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, alcohol>, <lorazepam, effect, barbiturates>, <lorazepam, effect, alcohol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Injection: Lorazepam injection, like other injectable benzodiazepines, produces depression of the central nervous system when administered with ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.When scopolamine is used concomitantly with injectable lorazepam, an increased incidence of sedation, hallucinations, and irrational behavior has been observed.
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<Lorazepam, effect, ethyl alcohol>, <Lorazepam, effect, phenothiazines>, <Lorazepam, effect, barbiturates>, <Lorazepam, effect, MAO inhibitors>, <Lorazepam, effect, antidepressants>, <benzodiazepines, effect, ethyl alcohol>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, MAO inhibitors>, <benzodiazepines, effect, antidepressants>, <scopolamine, effect, lorazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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(See CLINICAL PHARMACOLOGY) Coadministration of Femara and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels by 38% on average.
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<Femara, mechanism, tamoxifen>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects.
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<Codeine, effect, narcotic analgesics>, <Codeine, effect, anesthetics>, <Codeine, effect, phenothiazines>, <Codeine, effect, tranquilizers>, <Codeine, effect, sedative-hypnotics>, <Codeine, effect, CNS depressants>, <Codeine, effect, alcohol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.
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<SSRI, int, TCA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other.
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<TCAs, advise, SSRIs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Inhibitors or substrates of CYP2D6 (i.e., quinidine, selective serotonin reuptake inhibitors [SSRIs]) may increase the plasma concentration of doxepin when administered concomitantly.
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<quinidine, mechanism, doxepin>, <selective serotonin reuptake inhibitors, mechanism, doxepin>, <SSRIs, mechanism, doxepin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with SINEQUAN.
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<MAO inhibitors, advise, SINEQUAN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cimetidine: Cimetidine has been reported to produce clinically significant fluctuations in steady-state serum concentrations of various tricyclic antidepressants.
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<Cimetidine, mechanism, tricyclic antidepressants>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Serious anticholinergic symptoms (i.e., severe dry mouth, urinary retention and blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressant when cimetidine therapy is initiated.
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<tricyclic antidepressant, effect, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Additionally, higher than expected tricyclic antidepressant levels have been observed when they are begun in patients already taking cimetidine.
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<tricyclic antidepressant, mechanism, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In patients who have been reported to be well controlled on tricyclic antidepressants receiving concurrent cimetidine therapy, discontinuation of cimetidine has been reported to decrease established steady-state serum tricyclic antidepressant levels and compromise their therapeutic effects.
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<cimetidine, mechanism, tricyclic antidepressant>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Alcohol: It should be borne in mind that alcohol ingestion may increase the danger inherent in any intentional or unintentional SINEQUAN overdosage.
|
<alcohol, mechanism, SINEQUAN>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Tolazamide: A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 gm/day) 11 days after the addition of doxepin (75 mg/day).
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<tolazamide, effect, doxepin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine.
|
<barbiturates, effect, ketamine>, <narcotics, effect, ketamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Isocarboxazid should be administered with caution to patients receiving Antabuse (disulfiram, Wyeth-Ayerst Laboratories).
|
<Isocarboxazid, advise, Antabuse>, <Isocarboxazid, advise, disulfiram>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In a single study, rats given high intraperitoneal doses of an MAO inhibitor plus disulfiram experienced severe toxicity, including convulsions and death.
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<MAO inhibitor, effect, disulfiram>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant use of Isocarboxazid and other psychotropic agents is generally not recommended because of possible potentiating effects.
|
<Isocarboxazid, advise, psychotropic agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anesthetics/Sedatives/Hypnotics/Opioids: Co-administration of PRECEDEX with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects.
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<PRECEDEX, effect, anesthetics>, <PRECEDEX, effect, sedatives>, <PRECEDEX, effect, hypnotics>, <PRECEDEX, effect, opioids>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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However, due to possible pharmacodynamic interactions, when co-administered with PRECEDEX, a reduction in dosage of PRECEDEX on the concomitant anesthetic, sedative, hypnotic or opioid may be required.
|
<PRECEDEX, advise, anesthetic>, <PRECEDEX, advise, sedative>, <PRECEDEX, advise, hypnotic>, <PRECEDEX, advise, opioid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction.
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<aspirin, advise, carbonic anhydrase inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard.
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<Digoxin, effect, Adenocard>, <verapamil, effect, Adenocard>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.
|
<Adenocard, effect, digitalis>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline.
|
<adenosine, effect, methylxanthines>, <adenosine, effect, caffeine>, <adenosine, effect, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective.
|
<methylxanthines, advise, adenosine>, <methylxanthines, advise, adenosine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Adenosine effects are potentiated by dipyridamole.
|
<Adenosine, effect, dipyridamole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Thus, smaller doses of adenosine may be effective in the presence of dipyridamole.
|
<adenosine, effect, dipyridamole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.
|
<adenosine, effect, carbamazepine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine: In a study in healthy volunteers, a one-week course of cimetidine at 400 mg b.i.d. with a single 5 mg dose of isradipine on the sixth day showed an increase in isradipine mean peak plasma concentrations (36%) and significant increase in area under the curve (50%).
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<cimetidine, mechanism, isradipine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If isradipine therapy is initiated in a patient currently receiving cimetidine careful monitoring for adverse reactions is advised and downward dose adjustment may be required.
|
<isradipine, advise, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Rifampicin: In a study in healthy volunteers, a six-day course of rifampicin at 600 mg/day followed by a single 5 mg dose of isradipine resulted in a reduction in isradipine levels to below detectable limits.
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<rifampicin, mechanism, isradipine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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If rifampicin therapy is required, isradipine concentrations and therapeutic effects are likely to be markedly reduced or abolished as a consequence of increased metabolism and higher clearance of isradipine.
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<rifampicin, mechanism, isradipine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker.
|
<fentanyl, effect, beta blocker>, <fentanyl, effect, calcium channel blocker>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Drugs which induce CYP3A4 activity (eg, phenobarbital, rifampin, rifabutin) would be expected to increase the clearance of efavirenz resulting in lowered plasma concentrations.
|
<phenobarbital, mechanism, efavirenz>, <rifampin, mechanism, efavirenz>, <rifabutin, mechanism, efavirenz>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In uninfected volunteers, 46% developed rash while receiving SUSTIVA and clarithromycin.
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<SUSTIVA, effect, clarithromycin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to SUSTIVA.
|
<indinavir, mechanism, SUSTIVA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When indinavir at an increased dose (1000 mg every 8 hours) was given with SUSTIVA (600 mg once daily), the indinavir AUC and Cmin were decreased on average by 33-46% and 39-57%, respectively, compared to when indinavir (800 mg every 8 hours) was given alone.
|
<indinavir, mechanism, SUSTIVA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
A dose increase of lopinavir/ritonavir to 533/133 mg (4 capsules or 6.5 mL) twice daily taken with food is recommended when used in combination with SUSTIVA.
|
<lopinavir, advise, SUSTIVA>, <ritonavir, advise, SUSTIVA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Because the potential interaction of efavirenz with oral contraceptives has not been fully characterized, a reliable method of barrier contraception should be used in addition to oral contraceptives.
|
<efavirenz, advise, contraceptives>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Monitoring of liver enzymes is recommended when SUSTIVA is used in combination with ritonavir.
|
<SUSTIVA, advise, ritonavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Potential for reduction in anticonvulsant and/or efavirenz plasma levels;
|
<anticonvulsant, mechanism, efavirenz>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
SUSTIVA has the potential to decrease plasma concentrations of itraconazole and ketoconazole.
|
<SUSTIVA, mechanism, itraconazole>, <SUSTIVA, mechanism, ketoconazole>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Indinavir steady-state Cmax, A.C. and Cmin were decreased by 22%, 38%, and 27%, respectively, by concomitant amprenavir.
|
<Indinavir, mechanism, amprenavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Saquinavir steady-state Cmax, A.C. and Cmin were increased 21%, decreased 19%, and decreased 48%, respectively, by concomitant amprenavir.
|
<Saquinavir, mechanism, amprenavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Nelfinavir steady-state Cmax, A.C. and Cmin were increased by 12%, 15%, and 14%, respectively, by concomitant amprenavir.
|
<Nelfinavir, mechanism, amprenavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Methadone: Coadministration of amprenavir and methadone can decrease plasma levels of methadone.
|
<amprenavir, effect, methadone>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Coadministration of amprenavir and methadone as compared to a non-matched historicalcontrol group resulted in a 30%, 27%, and 25% decrease in serum amprenavir AUC, Cmax, andCmin, respectively.
|
<amprenavir, mechanism, methadone>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Laboratory Tests: The combination of Amprenavir and low-dose ritonavir has been associated with elevations of cholesterol and triglycerides, SGOT (AST), and SGPT (ALT) in some patients.
|
<Amprenavir, effect, ritonavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Appropriate laboratory testing should be considered prior to initiating combination therapy with Amprenavir and ritonavir and at periodic intervals or if any clinical signs or symptoms of hyperlipidemia or elevated liver function tests occur during therapy.
|
<Amprenavir, advise, ritonavir>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Corticotropin may accentuate the electrolyte loss associated with diuretic therapy.
|
<Corticotropin, effect, diuretic>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Beta-adrenergic Blocking Agents: Experience in over 1400 patients in a non-comparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension or exacerbation of angina.
|
<nifedipine, effect, beta-blocking agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Digitalis: Immediate Release Capsules: Since there have been isolated reports of patients with elevated digoxin levels, and there is a possible interaction between digoxin and nifedipine, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.
|
<digoxin, int, nifedipine>, <digoxin, advise, nifedipine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Extended Release Tablets: Administration of nifedipine with digoxin increased digoxin levels in 9 of 12 normal volunteers.
|
<digoxin, mechanism, digoxin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.
|
<digoxin, advise, nifedipine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Quinidine: Immediate Release Capsules: There have been rare reports of an interaction between quinidine and nifedipine (with a decreased plasma level of quinidine).
|
<quinidine, mechanism, nifedipine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Coumarin Anticoagulants: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered.
|
<coumarin anticoagulants, effect, nifedipine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cimetidine: A study in 6 healthy volunteers has shown a significant increase in peak nifedipine plasma levels (80%) and area-under-the-curve (74%) after a 1 week course of cimetidine at 1000 mg per day and nifedipine at 40 mg per day.
|
<cimetidine, mechanism, nifedipine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If nifedipine therapy is initiated in a patient currently receiving cimetidine, cautious titration is advised.
|
<nifedipine, advise, cimetidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins;
|
<Cholestyramine, mechanism, fat soluble vitamins>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia.
|
<thiazides, effect, vitamin D>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.
|
<Vitamin D, advise, digitalis>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Ketoconazole: Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D.
|
<Ketoconazole, mechanism, vitamin D>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Corticosteroids: A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.
|
<vitamin D, effect, corticosteroids>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Magnesium: Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.
|
<Magnesium, effect, vitamin D>, <antacids, effect, vitamin D>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin.
|
<diflunisal, mechanism, indomethacin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage.
|
<INDOCIN, effect, diflunisal>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, diflunisal and INDOCIN should not be used concomitantly.
|
<diflunisal, advise, INDOCIN>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.
|
<aspirin, mechanism, indomethacin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.
|
<INDOCIN, advise, NSAIDs>
|
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