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[
{
"role": "user",
"content": "You are an medical expert AI assistant specialized in Natural Language Inference (NLI) for clinical trial recruitment. The task is to determine if a patient's medical profile (written in medical language) Entails or Contradicts the eligibility criteria of a given Clinical Trial Report (CTR).\n\nYou will be provided with the Eligibility Criteria section of a CTR (denoted by **Clinical Trial Report Context:**), and a patient's medical profile (denoted by **Patient Description:**). Be as accurate and exact as possible.\n\n**Clinical Trial Report Context:** Inclusion Criteria:\n - Bone age less than equal to (</=) 9 years (females) or </= 11 years (males) as determined by X-ray of the left hand and wrist using Greulich and Pyle method and obtained within the 12 months prior to enrollment\n - Prepubertal (Tanner I) males and females by physical examination\n - Diagnosis of GHD (stimulated GH less than [<] 10 nanograms per milliliter [ng/mL]) by two standard pharmacologic tests obtained up to 12 months prior to informed consent/assent\n - Normal thyroid function test within the 12 months prior to informed consent/assent\n - Normal complete blood counts within 12 months prior to informed consent/assent\n - Documentation of prior height and weight measurements, with height standard deviation score (SDS) </= 5th percentile for idiopathic isolated GHD participants\n Exclusion Criteria:\n - Any previous rhGH treatment\n - Short stature etiologies other than GHD\n - Acute critical illness or uncontrolled chronic illness, which in the opinion of the investigator and medical monitor, would interfere with participation in this study, interpretation of the data, or pose a risk to participant safety\n - Chronic illnesses such as inflammatory bowel disease, celiac disease, heart disease, and diabetes\n - Bone diseases such as achondroplasia or hypochondroplasia, intracranial tumor, irradiation, and traumatic brain injury\n - Participants receiving oral or inhaled chronic corticosteroid therapy (greater than [>] 3 months) for other medical conditions other than central adrenal insufficiency\n - Participants who require higher (2 times or greater than maintenance) doses of corticosteroids for more than 5 days in the 6 months prior to enrollment in the study\n - Participants with active malignancy or any other condition that the investigator believes would pose a significant hazard to the participant if rhGH were initiated\n - Females with Turner syndrome regardless of their GH status\n - Prader-Willi syndrome regardless of GH status\n - Born small for gestational age regardless of GH status\n - Presence of scoliosis requiring monitoring\n - Previous participation in another clinical trial or investigation of GH, treatment for growth failure, or treatment with a biologic agent\n - Participants with closed epiphyses\n - Participants with a known hypersensitivity to somatropin, excipients, or diluent\nNo condition on gender to be admitted to the trial.\nNo healthy subjects accepted to join the trial.\nSubject must be at least 3 Years old.\nSubject must be at most 14 Years\n\n**Patient Description:** {{Description_Medical-Language}}\n\nPlease provide your judgement in a single word (Entailment or Contradiction), corresponding to the correct option that associates the Clinical Trial and the Patient Description.\n"
}
] |
[
{
"role": "assistant",
"content": "**Answer:** Contradiction\n"
}
] |
Contradiction
|
4,829
|
[
{
"role": "user",
"content": "You are an medical expert AI assistant specialized in Natural Language Inference (NLI) for clinical trial recruitment. The task is to determine if a patient's medical profile (written in medical language) Entails or Contradicts the eligibility criteria of a given Clinical Trial Report (CTR).\n\nYou will be provided with the Eligibility Criteria section of a CTR (denoted by **Clinical Trial Report Context:**), and a patient's medical profile (denoted by **Patient Description:**). Be as accurate and exact as possible.\n\n**Clinical Trial Report Context:** INCLUSION CRITERIA:\n Patients with Cushing syndrome documented at the NIH will be recruited into this protocol prior to surgery intended to cure Cushing syndrome selectively. Thus, patients undergoing transsphenoidal exploration for resection of an adenoma, or unilateral adrenalectomy for an adenoma, or resection of a tumor producing ACTH ectopically will be candidates for this study. We will also recruit as many of the 500 patients treated since 1983 as possible, so as to have a group of \"late follow-up\" patients. These individuals will participate primarily by questionnaire.\n Hematocrit about 30%. A CBC will be obtained prior to entering the study. Patients with hematocrit above 30% will be accepted into the study; iron replacement will be given to those patients with low TIBC.\n Ages 18 - 85. Children less than 18 are being studied under other protocols and the questionnaire has not been validated for younger individuals.\n For the questionnaire portion of the protocol there is an additional inclusion criterion:\n Patients must be able to read and write in English.\n EXCLUSION CRITERIA:\n There are no formal exclusion criteria, if the patient meets the inclusion criteria above. All ethnic groups and both genders will be recruited. However, patients may be withdrawn from the study by the PI if they are unable to meet study requirments, such as mailing questionnaires.\nNo condition on gender to be admitted to the trial.\nNo healthy subjects accepted to join the trial.\n\n\n\n**Patient Description:** {{Description_Medical-Language}}\n\nPlease provide your judgement in a single word (Entailment or Contradiction), corresponding to the correct option that associates the Clinical Trial and the Patient Description.\n"
}
] |
[
{
"role": "assistant",
"content": "**Answer:** Contradiction\n"
}
] |
Contradiction
|
4,452
|
[
{
"role": "user",
"content": "You are an medical expert AI assistant specialized in Natural Language Inference (NLI) for clinical trial recruitment. The task is to determine if a patient's medical profile (written in medical language) Entails or Contradicts the eligibility criteria of a given Clinical Trial Report (CTR).\n\nYou will be provided with the Eligibility Criteria section of a CTR (denoted by **Clinical Trial Report Context:**), and a patient's medical profile (denoted by **Patient Description:**). Be as accurate and exact as possible.\n\n**Clinical Trial Report Context:** Inclusion Criteria:\n - All patients presenting to the WRNMMC orthopaedic hand surgery clinic for complaints of lateral elbow pain will be evaluated for inclusion in the study. Inclusions criteria will be:\n - Clinical diagnosis of lateral epicondylitis based on primary complaint of lateral elbow pain and either (a) tenderness over the lateral epicondyle with direct palpation, or (b) exacerbation of pain at the lateral elbow with resisted dorsiflexion of the wrist\n - Failure of previous trial of non-operative management of at least 4wks duration (to include rest/light duty, non steroidal anti-inflammatory drugs , physical/occupational therapy, home stretching regimen)\n Exclusion Criteria:\n - Age <18yo\n - Pregnant or planning to become pregnant during study period (based on verbal questioning)\n - Steroid treatment (oral or injectable) within the previous 3mo\n - Diagnosis of ipsilateral compressive neuropathy\n - Allergy to Kenalog, lidocaine, or conductive ultrasound gel\n - Diagnosis of inflammatory arthropathy or rheumatoid conditions\n - Diagnosis of fibromyalgia, chronic fatigue syndrome, complex regional pain syndrome, or other chronic widespread pain syndromes\nNo condition on gender to be admitted to the trial.\nAccepts Healthy Volunteers\nSubject must be at least 18 Years old.\n\n\n**Patient Description:** {{Description_Medical-Language}}\n\nPlease provide your judgement in a single word (Entailment or Contradiction), corresponding to the correct option that associates the Clinical Trial and the Patient Description.\n"
}
] |
[
{
"role": "assistant",
"content": "**Answer:** Contradiction\n"
}
] |
Contradiction
|
2,669
|
[
{
"role": "user",
"content": "You are an medical expert AI assistant specialized in Natural Language Inference (NLI) for clinical trial recruitment. The task is to determine if a patient's medical profile (written in medical language) Entails or Contradicts the eligibility criteria of a given Clinical Trial Report (CTR).\n\nYou will be provided with the Eligibility Criteria section of a CTR (denoted by **Clinical Trial Report Context:**), and a patient's medical profile (denoted by **Patient Description:**). Be as accurate and exact as possible.\n\n**Clinical Trial Report Context:** Inclusion Criteria:\n - All patients fit for general anesthesia and presenting an inguinal hernia.\n Exclusion Criteria:\n - Not fit for general anesthesia, young age (>21 years), not wanting a mesh.\nNo condition on gender to be admitted to the trial.\nAccepts Healthy Volunteers\nSubject must be at least 21 Years old.\n\n\n**Patient Description:** {{Description_Medical-Language}}\n\nPlease provide your judgement in a single word (Entailment or Contradiction), corresponding to the correct option that associates the Clinical Trial and the Patient Description.\n"
}
] |
[
{
"role": "assistant",
"content": "**Answer:** Entailment\n"
}
] |
Entailment
|
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