vladak/string_ppi_human_1M

STRING PPI Human 1M

This dataset contains 1 million human protein–protein interactions (PPIs) derived from STRING v11.5.

Columns:

• seq_a, seq_b: Amino acid sequences of the interacting proteins (≤2048 AA).
• seq_name_a, seq_name_b: Protein names from STRING.
• score: Combined score from STRING (0–1000, normalized to 0–1). This score integrates various evidence channels (experimental data, text mining, co-expression, etc.) into a single confidence metric.
• label: Binary interaction label.
  • 1: High-confidence positive interaction (STRING experimental score > 0.7).
  • 0: Low-confidence negative interaction (STRING experimental score < 0.2).

Processing Steps:

• Downloaded human interactions from STRING (9606.protein.links.detailed.v11.5.txt.gz).
• Filtered by experimental score thresholds for positives/negatives.
• Retrieved protein sequences from UniProt by matching STRING protein names.
• Excluded sequences longer than 2048 amino acids.
• Balanced top and bottom 500k interactions by combined score.

Useful for training models for binary PPI prediction or embedding-based methods.

Source: STRING Database v11.5.