Datasets:
SkyHuReal
/
DrugBank-Alpaca

Dataset card Data Studio Files
xet
Community
1
instruction
stringclasses
1 value
input
stringlengths
42
1.01k
output
stringlengths
16
2.12k
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
If a diuretic is also used, it may increase the risk of lithium toxicity.
<diuretic, effect, lithium>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;
<TRACRIUM, effect, enflurane>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Drugs which may enhance the neuromuscular blocking action of TRACRIUM include: enflurane;isoflurane;halothane;certain antibiotics, especially the aminoglycosides and polymyxins;lithium;magnesium salts;procainamide;and quinidine.
<TRACRIUM, effect, enflurane>, <TRACRIUM, effect, isoflurane>, <TRACRIUM, effect, halothane>, <TRACRIUM, effect, antibiotics>, <TRACRIUM, effect, aminoglycosides>, <TRACRIUM, effect, polymyxins>, <TRACRIUM, effect, lithium>, <TRACRIUM, effect, magnesium>, <TRACRIUM, effect, procainamide>, <TRACRIUM, effect, quinidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The prior administration of succinylcholine does not enhance the duration, but quickens the onset and may increase the depth, of neuromuscular block induced by TRACRIUM.
<succinylcholine, effect, TRACRIUM>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
TRACRIUM should not be administered until a patient has recovered from succinylcholine-induced neuromuscular block.
<TRACRIUM, advise, succinylcholine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Potential drug interactions for doxylamine include, increased sedation if doxylamine is combined with other CNS depressant drugs.
<doxylamine, effect, CNS depressant drugs>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Antihistamines may partially counteract the anticoagulation effects of heparin or warfarin.
<Antihistamines, effect, heparin>, <Antihistamines, effect, warfarin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Doxylamine may enhance the effects of epinephrine.
<Doxylamine, effect, epinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.
<NSAIDs, effect, ACE inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Concomitant administration of naproxen and aspirin is not recommended because naproxen is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.
<naproxen, advise, aspirin>, <naproxen, advise, aspirin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Naproxen and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.
<Naproxen, effect, propranolol>, <Naproxen, effect, beta-blockers>, <NSAIDs, effect, propranolol>, <NSAIDs, effect, beta-blockers>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly.
<Probenecid, mechanism, naproxen>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Caution should be used if naproxen is administered concomitantly with methotrexate.
<naproxen, advise, methotrexate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Naproxen, naproxen sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.
<Naproxen, mechanism, methotrexate>, <naproxen sodium, mechanism, methotrexate>, <NSAIDs, mechanism, methotrexate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.
<CEFOTAN, effect, aminoglycoside>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Colchicine is inhibited by acidifying agents.
<Colchicine, mechanism, acidifying agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The action of colchicine is potentiated by alkalinizing agents.
<colchicine, mechanism, alkalinizing agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Colchicine may increase sensitivity to the CNS depressants.
<Colchicine, effect, CNS depressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Response to sympathomimetic agents may be enhanced by colchicine.
<sympathomimetic agents, effect, colchicine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Anagrelide alone had no effect on platelet aggregation, but did slightly enhance the inhibition of platelet aggregation by aspirin.
<Anagrelide, effect, aspirin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
It is known that CYP1A2 is inhibited by several medicinal products, including fluvoxamine, and such medicinal products could theoretically adversely influence the clearance of anagrelide.
<fluvoxamine, mechanism, anagrelide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Anagrelide demonstrates some limited inhibitory activity towards CYP1A2 which may present a theoretical potential for interaction with other coadministered medicinal products sharing that clearance mechanism e.g. theophylline.
<Anagrelide, mechanism, theophylline>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.
<milrinone, effect, anagrelide>, <enoximone, effect, anagrelide>, <amrinone, effect, anagrelide>, <olprinone, effect, anagrelide>, <cilostazol, effect, anagrelide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption.
<sucralfate, mechanism, anagrelide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.
<FLUOTHANE, effect, non-depolarising muscle relaxant>, <FLUOTHANE, effect, aminoglycosides>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.
<FLUOTHANE, effect, tubocurarine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated.
<adrenaline, advise, FLUOTHANE>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects
<Accutane, effect, vitamin A>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines
<Accutane, advise, tetracyclines>, <Accutane, effect, tetracyclines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations (minipills that do not contain an estrogen) may be an inadequate method of contraception during Accutane therapy.
<progesterone, effect, Accutane>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents.
<reserpine, effect, beta-blocking>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Should it be decided to discontinue therapy in patients receiving beta-blockers and clonidine concurrently, the beta-blocker should be discontinued slowly over several days before the gradual withdrawal of clonidine.
<beta-blockers, advise, clonidine>, <beta-blocker, advise, clonidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Literature reports suggest that oral calcium antagonists may be used in combination with beta-adrenergic blocking agents when heart function is normal, but should be avoided in patients with impaired cardiac function.
<calcium antagonists, advise, beta-adrenergic blocking agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Hypotension, AV conduction disturbances, and left ventricular failure have been reported in some patients receiving beta-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.
<beta-adrenergic blocking agents, effect, calcium antagonist>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Risk of Anaphylactic Reaction: Although it is known that patients on beta-blockers may be refractory to epinephrine in the treatment of anaphylactic shock, beta-blockers can, in addition, interfere with the modulation of allergic reaction and lead to an increased severity and/or frequency of attacks.
<beta-blockers, effect, epinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The potential for increased sedation when guanfacine is given with other CNS-depressant drug should be appreciated.
<guanfacine, effect, CNS-depressant drug>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The administration of guanfacine concomitantly with known microsomal enzyme inducer (phenobarbital or phenytoin) to two patients with renal impairment reportedly resulted in significant reductions in elimination half-life and plasma concentration.
<guanfacine, mechanism, phenobarbital>, <guanfacine, mechanism, phenytoin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
TCAs decrease the hypotensive effect of guanfacine.
<TCAs, effect, guanfacine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Noncardioselective beta-blockers (nadolol,porpranolol,timolol) may exacerbate rebound hypertension when guanfacine is withdrawn.
<Noncardioselective beta-blockers, effect, guanfacine>, <nadolol, effect, guanfacine>, <timolol, effect, guanfacine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved.
<SSRI, int, TCA>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Nevertheless, caution is indicated in the co-administration of T.A. with any of the SSRIs and also in switching from one class to the other.
<T.A., advise, SSRIs>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
If desipramine hydrochloride is to be combined with other psychotropic agents such as tranquilizers or sedative/hypnotics, careful consideration should be given to the pharmacology of the agents employed since the sedative effects of desipramine and benzodiazepines (e.g., chlordiazepoxide or diazepam) are additive.
<desipramine hydrochloride, effect, psychotropic agents>, <desipramine hydrochloride, effect, tranquilizers>, <desipramine hydrochloride, effect, sedative>, <desipramine hydrochloride, effect, hypnotics>, <desipramine, effect, benzodiazepines>, <desipramine, effect, chlordiazepoxide>, <desipramine, effect, diazepam>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Both the sedative and anticholinergic effects of the major tranquilizers are also additive to those of desipramine.
<major tranquilizers, effect, desipramine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Concurrent administration of cimetidine and tricyclic antidepressants can produce clinically significant increases in the plasma levels of the tricyclic antidepressants.
<cimetidine, mechanism, tricyclic antidepressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Conversely, decreases in plasma levels of the tricyclic antidepressants have been reported upon discontinuation of cimetidine which may result in the loss of the therapeutic efficacy of the tricyclic antidepressant 6.
<tricyclic antidepressants, mechanism, cimetidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
There have been greater than two-fold increases of previously stable plasma levels of tricyclic antidepressants when fluoxetine has been administered in combination with these agents.
<tricyclic antidepressants, mechanism, fluoxetine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
however, 150 mg of ranitidine q12h for 3 days increased the ceftibuten C max by 23% and ceftibuten AUC by 16%.
<ranitidine, mechanism, ceftibuten>, <ranitidine, mechanism, ceftibuten>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
FLEXERIL may have life-threatening interactions with MAO inhibitors.
<FLEXERIL, int, MAO inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.
<FLEXERIL, effect, alcohol>, <FLEXERIL, effect, barbiturates>, <FLEXERIL, effect, CNS depressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.
<Tricyclic antidepressants, effect, guanethidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol
<Tricyclic antidepressants, effect, tramadol>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Urinary acidifying agents These agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion.
<ammonium chloride, mechanism, amphetamine>, <sodium acid phosphate, mechanism, amphetamine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Adrenergic blockers Adrenergic blockers are inhibited by amphetamines.
<Adrenergic blockers, effect, amphetamines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Antidepressants, tricyclic Amphetamines may enhance the activity of tricyclic antidepressants or sympathomimetic agents;
<Amphetamines, effect, tricyclic antidepressants>, <Amphetamines, effect, sympathomimetic agents>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain;
<d-amphetamine, mechanism, desipramine>, <d-amphetamine, mechanism, protriptyline>, <d-amphetamine, mechanism, tricyclics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
MAO inhibitors MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.
<MAOI antidepressants, mechanism, amphetamine>, <furazolidone, mechanism, amphetamine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Antihistamines: Amphetamines may counteract the sedative effect of antihistamines.
<Amphetamines, effect, antihistamines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Antihypertensives: Amphetamines may antagonize the hypotensive effects of antihypertensives.
<Amphetamines, effect, antihypertensives>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines and can be used to treat amphetamine poisoning.
<Chlorpromazine, effect, amphetamines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide.
<Amphetamines, mechanism, ethosuximide>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Haloperidol: Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines.
<Haloperidol, effect, amphetamines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Lithium carbonate: The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate.
<amphetamines, effect, lithium carbonate>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Meperidine: Amphetamines potentiate the analgesic effect of meperidine.
<Amphetamines, effect, meperidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Methenamine therapy Urinary excretion of amphetamines is increased, and efficacy is reduced by acidifying agents used in methenamine therapy.
<amphetamines, mechanism, methenamine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine.
<Amphetamines, effect, norepinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital;
<Amphetamines, mechanism, phenobarbital>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Phenytoin: Amphetamines may delay intestinal absorption of phenytoin;
<Amphetamines, mechanism, phenytoin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur.
<propoxyphene, effect, amphetamine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids.
<Amphetamines, effect, veratrum alkaloids>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Intestinal adsorbents (e. g., charcoal) and digestive enzyme preparations containing carbohydrate-splitting enzymes (e. g., amylase, pancreatin) may reduce the effect of Acarbose and should not be taken concomitantly.
<Intestinal adsorbents, mechanism, Acarbose>, <charcoal, mechanism, Acarbose>, <amylase, mechanism, Acarbose>, <pancreatin, mechanism, Acarbose>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Acarbose has been shown to change the bioavailabillty digoxin when they are co-administered, which may require digoxin dose adjustment.
<Acarbose, mechanism, digoxin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
However, the peak plasma level of metformin was reduced by approximately 20% when taking Acarbose due to a slight delay in the absorption of metformin.
<metformin, mechanism, Acarbose>, <Acarbose, mechanism, metformin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Cyclopentolate may interfere with the anti-glaucoma action of carbachol or pilocarpine;
<Cyclopentolate, effect, carbachol>, <Cyclopentolate, effect, pilocarpine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Co-medications that induce CYP 3A4 (e.g., rifampicin, phenytoin, carbamazepine, phenobarbital, or St. John s wort) may significantly decrease exposure to exemestane.
<rifampicin, mechanism, exemestane>, <phenytoin, mechanism, exemestane>, <carbamazepine, mechanism, exemestane>, <phenobarbital, mechanism, exemestane>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
A case report of one patient taking amiodarone 200 mg and indinavir 800 mg three times a day resulted in increases in amiodarone concentrations from 0.9 mg/L to 1.3 mg/L.
<amiodarone, mechanism, indinavir>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Monitoring for amiodarone toxicity and serial measurement of amiodarone serum concentration during concomitant protease inhibitor therapy should be considered.
<amiodarone, advise, protease inhibitor>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Histamine H2 antagonists: Cimetidine inhibits CYP3A4 and can increase serum amiodarone levels.
<Histamine H2 antagonists, mechanism, Cimetidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
On administration of oral amiodarone, the need for digitalis therapy should be reviewed and the dose reduced by approximately 50% or discontinued.
<amiodarone, advise, digitalis>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction).
<Nafazodone, advise, Xanax>, <fluvoxamine, advise, Xanax>, <cimetidine, advise, Xanax>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Concomitant use of calcium supplements and L-lysine may increase calcium absorption
<calcium, mechanism, L-lysine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Hypertensive crises have resulted when sympathomimetic amines have been used concomitantly within14 days following use of monoamine oxidase inhibitors.
<sympathomimetic amines, effect, monoamine oxidase inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
DIDREX should not be used concomitantly with other CNS stimulants.
<DIDREX, advise, CNS stimulants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Amphetamines may decrease the hypotensive effect of antihypertensives.
<Amphetamines, effect, antihypertensives>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Amphetamines may enhance the effects of tricyclic antidepressants.
<Amphetamines, effect, tricyclic antidepressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Urinary acidifying agents decrease blood levels and increase excretion of amphetamines.
<Urinary acidifying, mechanism, amphetamines>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone.
<labetalol HCl, effect, tricyclic antidepressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Cimetidine has been shown to increase the bioavailability of labetalol HCl.
<Cimetidine, mechanism, labetalol HCl>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl.
<halothane, effect, labetalol HCl>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure.
<labetalol HCl, effect, halothane>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect.
<Labetalol HCl, effect, nitroglycerin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.
<labetalol HCl, effect, nitroglycerin>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.
<labetalol, advise, calcium antagonist>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
In clinical trials in patients undergoing PTCA/PCI, co-administration of Angiomax with heparin, warfarin, thrombolytics or glycoprotein IIb/IIIa inhibitors was associated with increased risks of major bleeding events compared to patients not receiving these concomitant medications.
<Angiomax, effect, heparin>, <Angiomax, effect, warfarin>, <Angiomax, effect, thrombolytics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension.
<epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine.
<Phenothiazines, effect, epinephrine>, <butyrophenones, effect, epinephrine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Drug Interactions with Beta-Blockers: Concomitant use of fenoldopam with beta-blockers should be avoided.
<fenoldopam, advise, beta-blockers>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Apraclonidine should not be used in patients receiving MAO inhibitors..
<Apraclonidine, advise, MAO inhibitors>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Although no specific drug interactions with topical glaucoma drugs or systemic medications were identified in clinical studies of IOPIDINE 0.5% Ophthalmic Solution, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, anesthetics) should be considered.
<IOPIDINE, advise, CNS depressants>, <IOPIDINE, advise, alcohol>, <IOPIDINE, advise, barbiturates>, <IOPIDINE, advise, opiates>, <IOPIDINE, advise, sedatives>, <IOPIDINE, advise, anesthetics>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.
<Tricyclic antidepressants, effect, clonidine>
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
An additive hypotensive effect has been reported with the combination of systemic clonidine and neuroleptic therapy.
<clonidine, effect, neuroleptic>