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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Caution should be exercised if an HMG-CoA reductase inhibitor is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine.
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<HMG-CoA reductase inhibitor, advise, ketoconazole>, <HMG-CoA reductase inhibitor, advise, spironolactone>, <HMG-CoA reductase inhibitor, advise, cimetidine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Before taking glimepiride, tell your doctor if you are taking any of the following medicines: - aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);
|
<glimepiride, advise, aspirin>, <glimepiride, advise, salicylate>, <glimepiride, advise, magnesium/choline salicylate>, <glimepiride, advise, Trilisate>, <glimepiride, advise, salsalate>, <glimepiride, advise, Disalcid>, <glimepiride, advise, choline salicylate>, <glimepiride, advise, Arthropan>, <glimepiride, advise, magnesium salicylate>, <glimepiride, advise, Magan>, <glimepiride, advise, bismuth subsalicylate>, <glimepiride, advise, Pepto-Bismol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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HEMABATE may augment the activity of other oxytocic agents.
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<HEMABATE, effect, oxytocic agents>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.
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<Furosemide, effect, aminoglycoside antibiotics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
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<Furosemide, advise, ethacrynic acid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
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<salicylates, effect, furosemide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.
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<Furosemide, effect, tubocurarine>, <Furosemide, effect, succinylcholine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.
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<Lithium, advise, diuretics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide may add to or potentiate the therapeutic effect of other antihypertensive drugs.
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<Furosemide, effect, antihypertensive drugs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Furosemide may decrease arterial responsiveness to norepinephrine.
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<Furosemide, effect, norepinephrine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tablets Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide.
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<sucralfate, effect, furosemide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The intake of furosemide and sucralfate should be separated by at least two hours.
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<furosemide, advise, sucralfate>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tablets, Injection, and Oral Solution One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency.
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<furosemide, effect, acetylsalicylic acid>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
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<furosemide, effect, NSAIDs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis.
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<indomethacin, effect, furosemide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.
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<indomethacin, advise, furosemide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Warfarin: Meclofenamate sodium enhances the effect of warfarin.
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<Warfarin, effect, Meclofenamate sodium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, when meclofenamate sodium is given to a patient receiving warfarin, the dosage of warfarin should be reduced to prevent excessive prolongation of the prothrombin time.
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<meclofenamate sodium, advise, warfarin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Aspirin: Concurrent administration of aspirin may lower meclofenamate sodium plasma levels, possibly by competing for protein-binding sites.
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<aspirin, mechanism, meclofenamate sodium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
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<oxyphenbutazone, mechanism, androgens>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.
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<androgens, effect, insulin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins.
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<Chloramphenicol, effect, penicillins>, <erythromycins, effect, penicillins>, <sulfonamides, effect, penicillins>, <tetracyclines, effect, penicillins>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity.
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<Probenecid, mechanism, ampicillin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Digoxin: In controlled studies in healthy volunteers, bepridil hydrochloride either had no effect (one study) or was associated with modest increases, about 30% (two studies) in steady-state serum digoxin concentrations.
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<bepridil hydrochloride, mechanism, digoxin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Anti-arrhythmics and tricyclic anti-depressants could exaggerate the prolongation of the QT interval observed with bepridil hydrochloride.
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<Anti-arrhythmics, effect, bepridil hydrochloride>, <tricyclic anti-depressants, effect, bepridil hydrochloride>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cardiac glycosides could exaggerate the depression of AV nodal conduction observed with bepridil hydrochloride.
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<Cardiac glycosides, effect, bepridil hydrochloride>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.
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<Tetracycline, effect, penicillin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.
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<Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa.
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<Dopamine D2 receptor antagonists, effect, levodopa>, <phenothiazines, effect, levodopa>, <butyrophenones, effect, levodopa>, <risperidone, effect, levodopa>, <isoniazid, effect, levodopa>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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In addition, the beneficial effects of levodopa in Parkinsons disease have been reported to be reversed by phenytoin and papaverine.
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<levodopa, effect, phenytoin>, <levodopa, effect, papaverine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Iron salts may reduce the bioavailability of carbidopa and levodopa.
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<Iron, mechanism, carbidopa>, <Iron, mechanism, levodopa>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.
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<metoclopramide, mechanism, levodopa>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Since hydroxyurea may raise the serum uric acid level, dosage adjustment of uricosuric medication may be necessary
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<hydroxyurea, effect, uricosuric medication>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.
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<probenecid, mechanism, penciclovir>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics.
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<aminoglycoside antibiotics, effect, cephalosporin antibiotics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Concomitant administration of probenecid doubled the AUC for cefprozil.
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<probenecid, mechanism, cefprozil>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Both the magnitude and duration of central nervous system and cardiovascular effects may be enhanced when ALFENTA is administered in combination with other CNS depressants such as barbiturates, tranquilizers, opioids, or inhalation general anesthetics.
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<ALFENTA, effect, CNS depressants>, <ALFENTA, effect, barbiturates>, <ALFENTA, effect, tranquilizers>, <ALFENTA, effect, opioids>, <ALFENTA, effect, anesthetics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Limited clinical experience indicates that requirements for volatile inhalation anesthetics are reduced by 30 to 50% for the first sixty (60) minutes following ALFENTA induction The concomitant use of erythromycin with ALFENTA can significantly inhibit ALFENTA clearance and may increase the risk of prolonged or delayed respiratory depression.
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<volatile inhalation anesthetics, mechanism, ALFENTA>, <erythromycin, mechanism, ALFENTA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Cimetidine reduces the clearance of ALFENTA.
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<Cimetidine, mechanism, ALFENTA>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Diphenoxylate HCl and atropine sulfate may interact with MAO inhibitors In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system at a dose of 2 mg/kg/day.
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<Diphenoxylate HCl, int, MAO inhibitors>, <atropine sulfate, int, MAO inhibitors>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Although deferasirox has a lower affinity for aluminum than for iron, Exjade should not be taken with aluminum-containing antacid preparations.
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<Exjade, advise, aluminum>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The use of codeine may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.
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<codeine, effect, alcohol>, <codeine, effect, antihistamines>, <codeine, effect, psychotropics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs).
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<dextromethorphan, effect, monoamine oxidase inhibitors>, <dextromethorphan, effect, MAOIs>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.
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<dextromethorphan hydrobromide, effect, alcohol>, <dextromethorphan hydrobromide, effect, antihistamines>, <dextromethorphan hydrobromide, effect, psychotropics>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cholestyramine resin may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic) or propranolol (basic), as well as tetracycline penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis.
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<Cholestyramine, mechanism, phenylbutazone>, <Cholestyramine, mechanism, warfarin>, <Cholestyramine, mechanism, thiazide diuretics>, <Cholestyramine, mechanism, propranolol>, <Cholestyramine, mechanism, tetracycline>, <Cholestyramine, mechanism, penicillin G>, <Cholestyramine, mechanism, phenobarbital>, <Cholestyramine, mechanism, thyroxine>, <Cholestyramine, mechanism, estrogens>, <Cholestyramine, mechanism, progestins>, <Cholestyramine, mechanism, digitalis>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cholestyramine resin may interfere with the pharmacokinetics of drugs that undergo enterohepatic circulation, The discontinuance of cholestyramine resin could pose a hazard to health if a potentially toxic drug such as digitalis has been filtrated to a maintenance level while the patient was taking cholestyramine resin.
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<cholestyramine, mechanism, digitalis>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Agents that are CYP3A4 inhibitors that have been found, or are expected, to increase plasma levels of EQUETROTM are the following: Acetazolamide, azole antifungals, cimetidine, clarithromycin(1), dalfopristin, danazol, delavirdine, diltiazem, erythromycin(1), fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, loratadine, nefazodone, niacinamide, nicotinamide, protease inhibitors, propoxyphene, quinine, quinupristin, troleandomycin, valproate(1), verapamil, zileuton.
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<EQUETROTM, mechanism, Acetazolamide>, <EQUETROTM, mechanism, azole antifungals>, <EQUETROTM, mechanism, cimetidine>, <EQUETROTM, mechanism, clarithromycin>, <EQUETROTM, mechanism, dalfopristin>, <EQUETROTM, mechanism, danazol>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, diltiazem>, <EQUETROTM, mechanism, erythromycin>, <EQUETROTM, mechanism, fluoxetine>, <EQUETROTM, mechanism, fluvoxamine>, <EQUETROTM, mechanism, isoniazid>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, ketoconazole>, <EQUETROTM, mechanism, loratadine>, <EQUETROTM, mechanism, nefazodone>, <EQUETROTM, mechanism, niacinamide>, <EQUETROTM, mechanism, nicotinamide>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, propoxyphene>, <EQUETROTM, mechanism, quinine>, <EQUETROTM, mechanism, quinupristin>, <EQUETROTM, mechanism, troleandomycin>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, verapamil>, <EQUETROTM, mechanism, zileuton>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Agents that are CYP inducers that have been found, or are expected, to decrease plasma levels of EQUETROTM are the following: Cisplatin, doxorubicin HCL, felbamate, rifampin, phenobarbital, Phenytoin(2), primidone, methsuximide, and theophylline Thus, if a patient has been titrated to a stable dosage on EQUETROTM, and then begins a course of treatment with one of these CYP3A4 inducers, it is reasonable to expect that a dose increase for EQUETROTM may be necessary.
|
<EQUETROTM, mechanism, Cisplatin>, <EQUETROTM, mechanism, doxorubicin HCL>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, rifampin>, <EQUETROTM, mechanism, phenobarbital>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>, <EQUETROTM, mechanism, methsuximide>, <EQUETROTM, mechanism, theophylline>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Agents that have been found, or are expected to have decreased plasma levels in the presence of EQUETROTM due to induction of CYP enzymes are the following: Acetaminophen, alprazolam, amitriptyline, bupropion, buspirone, citalopram, clobazam, clonazepam, clozapine, cyclosporin, delavirdine, desipramine, diazepam, dicumarol, doxycycline, ethosuximide, felbamate, felodipine, glucocorticoids, haloperidol, itraconazole, lamotrigine, levothyroxine, lorazepam, methadone, midazolam, mirtazapine, nortriptyline, olanzapine, oral contraceptives(3), oxcarbazepine, Phenytoin(4), praziquantel, protease inhibitors, quetiapine, risperidone, theophylline, topiramate, tiagabine, tramadol, triazolam, valproate, warfarin(5) , ziprasidone, and zonisamide.
|
<EQUETROTM, mechanism, Acetaminophen>, <EQUETROTM, mechanism, alprazolam>, <EQUETROTM, mechanism, amitriptyline>, <EQUETROTM, mechanism, bupropion>, <EQUETROTM, mechanism, buspirone>, <EQUETROTM, mechanism, citalopram>, <EQUETROTM, mechanism, clobazam>, <EQUETROTM, mechanism, clonazepam>, <EQUETROTM, mechanism, clozapine>, <EQUETROTM, mechanism, cyclosporin>, <EQUETROTM, mechanism, delavirdine>, <EQUETROTM, mechanism, desipramine>, <EQUETROTM, mechanism, diazepam>, <EQUETROTM, mechanism, dicumarol>, <EQUETROTM, mechanism, doxycycline>, <EQUETROTM, mechanism, ethosuximide>, <EQUETROTM, mechanism, felbamate>, <EQUETROTM, mechanism, felodipine>, <EQUETROTM, mechanism, glucocorticoids>, <EQUETROTM, mechanism, haloperidol>, <EQUETROTM, mechanism, itraconazole>, <EQUETROTM, mechanism, lamotrigine>, <EQUETROTM, mechanism, levothyroxine>, <EQUETROTM, mechanism, lorazepam>, <EQUETROTM, mechanism, methadone>, <EQUETROTM, mechanism, midazolam>, <EQUETROTM, mechanism, mirtazapine>, <EQUETROTM, mechanism, nortriptyline>, <EQUETROTM, mechanism, olanzapine>, <EQUETROTM, mechanism, contraceptives>, <EQUETROTM, mechanism, oxcarbazepine>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, praziquantel>, <EQUETROTM, mechanism, protease inhibitors>, <EQUETROTM, mechanism, quetiapine>, <EQUETROTM, mechanism, risperidone>, <EQUETROTM, mechanism, theophylline>, <EQUETROTM, mechanism, topiramate>, <EQUETROTM, mechanism, tiagabine>, <EQUETROTM, mechanism, tramadol>, <EQUETROTM, mechanism, triazolam>, <EQUETROTM, mechanism, valproate>, <EQUETROTM, mechanism, warfarin>, <EQUETROTM, mechanism, ziprasidone>, <EQUETROTM, mechanism, zonisamide>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Agents with Increased Levels in the Presence of Carbamazepine: EQUETROTM increases the plasma levels of the following agents: Clomipramine HCl, Phenytoin(6), and primidone Thus, if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of the treatment with EQUETROTM, it is reasonable to expect that a dose decrease for the concomitant agent may be necessary.
|
<EQUETROTM, mechanism, Clomipramine HCl>, <EQUETROTM, mechanism, Phenytoin>, <EQUETROTM, mechanism, primidone>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Pharmacological/Pharmacodynamic Interactions with Carbamazepine Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.
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<carbamazepine, effect, lithium>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Additionally, anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine.
|
<anti-malarial drugs, effect, carbamazepine>, <chloroquine, effect, carbamazepine>, <mefloquine, effect, carbamazepine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Because of its primary CNS effect, caution should be used when EQUETROTM is taken with other centrally acting drugs and alcohol.
|
<EQUETROTM, advise, centrally acting drugs>, <EQUETROTM, advise, alcohol>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In patients receiving another serotonin reuptake inhibitor drug in combination with monoamine oxidase inhibitors (MAOI), there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.
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<serotonin reuptake inhibitor drug, effect, monoamine oxidase inhibitors>, <serotonin reuptake inhibitor drug, effect, MAOI>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Therefore, it is recommended that Fluvoxamine Tablets not be used in combination with MAOIs, or within 14 days of discontinuing treatment with a MAOI.
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<Fluvoxamine, advise, MAOIs>, <Fluvoxamine, advise, MAOI>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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After stopping Fluvoxamine Tablets, at least 2 weeks should be allowed before starting a MAOI.
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<Fluvoxamine, advise, MAOI>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Terfenadine, astemizole and cisapride are all metabolized by the cytochrome P450IIIA4 isozyme, and it has been demonstrated that ketoconazole, a potent inhibitor of IIIA4, blocks the metabolism of these drugs, resulting in increased plasma concentrations of parent drug.
|
<Terfenadine, mechanism, ketoconazole>, <astemizole, mechanism, ketoconazole>, <cisapride, mechanism, ketoconazole>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Although it has not been definitively demonstrated that fluvoxamine is a potent IIIA4 inhibitor, it is likely to be, given the substantial interaction of fluvoxamine with alprazolam.
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<fluvoxamine, int, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Consequently, it is recommended that fluvoxamine not be used in combination with either terbinafine, astemizole, or cisapride.
|
<fluvoxamine, advise, terbinafine>, <fluvoxamine, advise, astemizole>, <fluvoxamine, advise, cisapride>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Other Potentially Important Drug Interactions: Benzodiazepines: Benzodiazepines metabolized by hepatic oxidation (e.g., alprazolam, midazolam, triazolam elc.) should be used with caution because the clearance of these drugs is likely to be reduced by fluvoxamine.
|
<Benzodiazepines, mechanism, fluvoxamine>, <alprazolam, mechanism, fluvoxamine>, <midazolam, mechanism, fluvoxamine>, <triazolam, mechanism, fluvoxamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Alprazolam: When fluvoxamine maleate (100 mg qd) and alprazolam (1 mg q.d. were co-administered to steady state, plasma concentration and other pharmacokinetics parameters (AUC, Cmax, T1/2,) of alprazolam were approximately twice those observed when alprazolam was administered alone;
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<fluvoxamine maleate, mechanism, alprazolam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
This interaction, which has not been investigated using higher doses of fluvoxamine, may be more pronounced if a 300 mg daily dose is co-administered, particularly since fluvoxamine exhibits non-linear pharmacokinetics over the dosage range 100-300 mg. If alprazolam is co-administered with Fluvoxamine Tablets, the initial alprazolam dosage should be at least halved and titration to the lowest effective dose is recommended.
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<alprazolam, advise, Fluvoxamine>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
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Diazepam: The co-administration of Fluvoxamine Tablets and diazepam is generally not advisable.
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<Fluvoxamine, advise, diazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Because fluvoxamine reduces the clearance of both diazepam and its active metabolite, N-desmethyldiazepam, there is a strong likelihood of substantial accumulation of both species during chronic co-administration.
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<fluvoxamine, mechanism, diazepam>, <fluvoxamine, mechanism, N-desmethyldiazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Evidence supporting the conclusion that it is inadvisable to co-administer fluvoxamine and diazepam is derived from a study in which healthy volunteers taking 150 mg/day of fluvoxamine were administered a single oral dose of 10 mg of diazepam.
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<fluvoxamine, advise, diazepam>
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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Moreover, as noted with alprazolam, the effect of fluvoxamine may even be more pronounced when it is administered at higher doses.
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<alprazolam, effect, fluvoxamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Accordingly, diazepam and fluvoxamine should not ordinarily be co-administered.
|
<diazepam, advise, fluvoxamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, if theophylline is co-administered with fluvoxamine maleate, its dose should be reduced to one third of the usual daily maintenance dose and plasma concentrations of theophylline should to monitored.
|
<theophylline, advise, fluvoxamine maleate>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Warfarin: When fluvoxamine maleate (50 mg tid) was administered concomitantly with warfarin for two weeks, warfarin plasma concentrations increased by 98% and prothrombin times were prolonged.
|
<fluvoxamine maleate, mechanism, warfarin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Thus patients receiving oral anticoagulants and Fluvoxamine Tablets should have their prothrombin time monitored and their anticoagulant dose adjusted accordingly.
|
<anticoagulants, advise, Fluvoxamine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Therefore, caution should be used when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur (e.g., warfarin).
|
<nitazoxanide, mechanism, warfarin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The most commonly occurring drug interactions are listed below: - Drugs that may increase plasma phenytoin concentrations include: acute alcohol intake, amiodarone, chboramphenicol, chlordiazepoxide, cimetidine, diazepam, dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine, H2-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides, sulfonamides, tolbutamide, trazodone
|
<phenytoin, mechanism, alcohol>, <phenytoin, mechanism, amiodarone>, <phenytoin, mechanism, chlordiazepoxide>, <phenytoin, mechanism, cimetidine>, <phenytoin, mechanism, diazepam>, <phenytoin, mechanism, dicumarol>, <phenytoin, mechanism, disulfiram>, <phenytoin, mechanism, estrogens>, <phenytoin, mechanism, ethosuximide>, <phenytoin, mechanism, fluoxetine>, <phenytoin, mechanism, H2-antagonists>, <phenytoin, mechanism, halothane>, <phenytoin, mechanism, isoniazid>, <phenytoin, mechanism, methylphenidate>, <phenytoin, mechanism, phenothiazines>, <phenytoin, mechanism, phenylbutazone>, <phenytoin, mechanism, salicylates>, <phenytoin, mechanism, succinimides>, <phenytoin, mechanism, sulfonamides>, <phenytoin, mechanism, tolbutamide>, <phenytoin, mechanism, trazodone>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Drugs that may decrease plasma phenytoin concentrations include: carbamazepine, chronic alcohol abuse, reserpine
|
<phenytoin, mechanism, carbamazepine>, <phenytoin, mechanism, alcohol>, <phenytoin, mechanism, reserpine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Drugs that may either increase or decrease plasma phenytoin concentrations include: phenobarbital, vaiproic acid, and sodium valproate.
|
<phenytoin, mechanism, phenobarbital>, <phenytoin, mechanism, sodium valproate>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Similarly, the effects of phenytoin on phenobarbital, valproic acid and sodium plasma valproate concentrations are unpredictable
|
<phenytoin, effect, phenobarbital>, <phenytoin, effect, valproic acid>, <phenytoin, effect, valproate>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Although not a true drug interaction, tricyclic antidepressants may precipitate seizures in susceptible patients and Cerebyx dosage may need to be adjusted
|
<tricyclic antidepressants, effect, Cerebyx>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
- Drugs whose efficacy is impaired by phenytoin include: anticoagulants, corticosteroids, coumarin, digitoxin, doxycycline, estrogens, furosemide, oral contraceptives, rifampin, quinidine, theophylline, vitamin D.
|
<phenytoin, effect, anticoagulants>, <phenytoin, effect, corticosteroids>, <phenytoin, effect, coumarin>, <phenytoin, effect, digitoxin>, <phenytoin, effect, doxycycline>, <phenytoin, effect, estrogens>, <phenytoin, effect, furosemide>, <phenytoin, effect, contraceptives>, <phenytoin, effect, rifampin>, <phenytoin, effect, quinidine>, <phenytoin, effect, theophylline>, <phenytoin, effect, vitamin D>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Catecholamine-depleting drugs (eg, reserpine) may have an additive effect when given with beta-blocking agents.
|
<reserpine, effect, beta-blocking agent>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Calcium channel blockers may also have an additive effect when given with TENORMIN .
|
<Calcium channel blockers, effect, TENORMIN>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Beta blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
|
<Beta blockers, effect, clonidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If the two drugs are coadministered, the beta blocker should be withdrawn several days before the gradual withdrawal of clonidine.
|
<beta blocker, advise, clonidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
If replacing clonidine by beta-blocker therapy, the introduction of beta blockers should be delayed for several days after clonidine administration has stopped.
|
<beta blockers, advise, clonidine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.
|
<indomethacin, effect, beta blockers>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Interactions may occur between EPA supplements and aspirin and other non-steroidal anti-inflammatory drugs and herbs such as garlic (Allium sativum) and ginkgo (Ginkgo biloba).
|
<EPA, int, aspirin>, <EPA, int, non-steroidal anti-inflammatory drugs>, <EPA, int, ginkgo>, <EPA, int, Ginkgo biloba>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When administered concurrently, the following drugs may interact with amphotericin B: Antineoplastic agents: may enhance the potential for renal toxicity, bronchospasm and hypotension.
|
<amphotericin B, effect, Antineoplastic agents>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Corticosteroids and Corticotropin (ACTH): may potentiate amphotericin B- induced hypokalemia which may predispose the patient to cardiac dysfunction.
|
<Corticosteroids, effect, amphotericin B>, <Corticotropin, effect, amphotericin B>, <ACTH, effect, amphotericin B>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Digitalis glycosides: amphotericin B-induced hypokalemia may potentiate digitalis toxicity.
|
<amphotericin B, effect, digitalis>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Flucytosine: while a synergistic relationship with amphotericin B has been reported, concomitant use may increase the toxicity of flucytosine by possibly increasing its cellular uptake and/or impairing its renal excretion.
|
<amphotericin B, effect, flucytosine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Imidazoles (e. g., ketoconazole, miconazole, clotrimazole, fluconazole, etc.): in vitro and animal studies with the combination of amphotericin B and imidazoles suggest that imidazoles may induce fungal resistance to amphotericin B.
|
<imidazoles, effect, amphotericin B>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Skeletal muscle relaxants: amphotericin B-induced hypokalemia may enhance the curariform effect of skeletal muscle relaxants (e.g., tubocurarine).
|
<amphotericin B, effect, skeletal muscle relaxants>, <amphotericin B, effect, tubocurarine>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Leukocyte transfusions: acute pulmonary toxicity has been reported in patients receiving intravenous amphotericin B and leukocyte transfusions.
|
<amphotericin B, effect, leukocyte transfusions>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
The absorption of lymecycline may be affected by the simultaneous administration of indigestion remedies, iron or zinc supplements.
|
<lymecycline, mechanism, iron>, <lymecycline, mechanism, zinc>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Oral contraceptives may be less effective while you are taking lymecycline.
|
<contraceptives, effect, lymecycline>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Additional reductions in blood pressure may occur when FLOLAN is administered with diuretics, antihypertensive agents, or other vasodilators.
|
<FLOLAN, effect, diuretics>, <FLOLAN, effect, antihypertensive agents>, <FLOLAN, effect, vasodilators>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
When other antiplatelet agents or anticoagulants are used concomitantly, there is the potential for FLOLAN to increase the risk of bleeding.
|
<antiplatelet agents, effect, FLOLAN>, <anticoagulants, effect, FLOLAN>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
In clinical trials, FLOLAN was used with digoxin, diuretics, anticoagulants, oral vasodilators, and supplemental oxygen.In a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with FLOLAN was initiated, apparent oral clearance values for furosemide (n = 23) and digoxin (n = 30) were decreased by 13% and 15%, respectively, on the second day of therapy and had returned to baseline values by day 87.
|
<furosemide, mechanism, FLOLAN>, <digoxin, mechanism, FLOLAN>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
However, patients on digoxin may show elevations of digoxin concentrations after initiation of therapy with FLOLAN, which may be clinically significant in patients prone to digoxin toxicity.
|
<digoxin, mechanism, FLOLAN>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Cyclosporine - L-arginine may counteract the antinaturetic effect of cyclosporin.
|
<L-arginine, effect, cyclosporin>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Ibuprofen - L-arginine may increase the absorption of ibuprofen if taken concomitantly.
|
<L-arginine, mechanism, ibuprofen>
|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.
|
Organic nitrates - L-arginine supplements theoretically may potentiate the effects of organic nitrates if taken concomitantly.
|
<L-arginine, effect, nitrates>
|
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