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Nov 6

EU-Agent-Bench: Measuring Illegal Behavior of LLM Agents Under EU Law

Large language models (LLMs) are increasingly deployed as agents in various contexts by providing tools at their disposal. However, LLM agents can exhibit unpredictable behaviors, including taking undesirable and/or unsafe actions. In order to measure the latent propensity of LLM agents for taking illegal actions under an EU legislative context, we introduce EU-Agent-Bench, a verifiable human-curated benchmark that evaluates an agent's alignment with EU legal norms in situations where benign user inputs could lead to unlawful actions. Our benchmark spans scenarios across several categories, including data protection, bias/discrimination, and scientific integrity, with each user request allowing for both compliant and non-compliant execution of the requested actions. Comparing the model's function calls against a rubric exhaustively supported by citations of the relevant legislature, we evaluate the legal compliance of frontier LLMs, and furthermore investigate the compliance effect of providing the relevant legislative excerpts in the agent's system prompt along with explicit instructions to comply. We release a public preview set for the research community, while holding out a private test set to prevent data contamination in evaluating upcoming models. We encourage future work extending agentic safety benchmarks to different legal jurisdictions and to multi-turn and multilingual interactions. We release our code on https://github.com/ilijalichkovski/eu-agent-bench{this URL}.

  • 4 authors
·
Oct 24

ShieldAgent: Shielding Agents via Verifiable Safety Policy Reasoning

Autonomous agents powered by foundation models have seen widespread adoption across various real-world applications. However, they remain highly vulnerable to malicious instructions and attacks, which can result in severe consequences such as privacy breaches and financial losses. More critically, existing guardrails for LLMs are not applicable due to the complex and dynamic nature of agents. To tackle these challenges, we propose ShieldAgent, the first guardrail agent designed to enforce explicit safety policy compliance for the action trajectory of other protected agents through logical reasoning. Specifically, ShieldAgent first constructs a safety policy model by extracting verifiable rules from policy documents and structuring them into a set of action-based probabilistic rule circuits. Given the action trajectory of the protected agent, ShieldAgent retrieves relevant rule circuits and generates a shielding plan, leveraging its comprehensive tool library and executable code for formal verification. In addition, given the lack of guardrail benchmarks for agents, we introduce ShieldAgent-Bench, a dataset with 3K safety-related pairs of agent instructions and action trajectories, collected via SOTA attacks across 6 web environments and 7 risk categories. Experiments show that ShieldAgent achieves SOTA on ShieldAgent-Bench and three existing benchmarks, outperforming prior methods by 11.3% on average with a high recall of 90.1%. Additionally, ShieldAgent reduces API queries by 64.7% and inference time by 58.2%, demonstrating its high precision and efficiency in safeguarding agents.

  • 3 authors
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Mar 26 3

Diagnose, Localize, Align: A Full-Stack Framework for Reliable LLM Multi-Agent Systems under Instruction Conflicts

Large Language Model (LLM)-powered multi-agent systems (MAS) have rapidly advanced collaborative reasoning, tool use, and role-specialized coordination in complex tasks. However, reliability-critical deployment remains hindered by a systemic failure mode: hierarchical compliance under instruction conflicts (system-user, peer-peer), where agents misprioritize system-level rules in the presence of competing demands. Moreover, widely used macro-level metrics (e.g., pass@k) obscure these micro-level violations and offer little actionable guidance for remedy. In this work, we present a full-stack, three-stage framework: (1) Diagnose - Contextualized Role Adherence Score (CRAS), a query-wise, context-aware scoring metric that decomposes role adherence into four measurable dimensions; (2) Localize - attention drift analysis revealing that instruction conflicts are resolved by attention heads that are largely concentrated in middle layers; (3) Align - Surgical Alignment of Instruction Layers (SAIL), which installs LoRA only on the localized focal layers and optimizes a token-weighted DPO-style preference objective that credits tokens by their focal attentional contribution. Across standard benchmarks and MAS frameworks, our surgical approach improves instruction hierarchy compliance (e.g., +5.60% with AutoGen on MedQA) without full-model finetuning.

  • 13 authors
·
Sep 27

Towards Policy-Compliant Agents: Learning Efficient Guardrails For Policy Violation Detection

Autonomous web agents need to operate under externally imposed or human-specified policies while generating long-horizon trajectories. However, little work has examined whether these trajectories comply with such policies, or whether policy violations persist across different contexts such as domains (e.g., shopping or coding websites) and subdomains (e.g., product search and order management in shopping). To address this gap, we introduce PolicyGuardBench, a benchmark of about 60k examples for detecting policy violations in agent trajectories. From diverse agent runs, we generate a broad set of policies and create both within subdomain and cross subdomain pairings with violation labels. In addition to full-trajectory evaluation, PolicyGuardBench also includes a prefix-based violation detection task where models must anticipate policy violations from truncated trajectory prefixes rather than complete sequences. Using this dataset, we train PolicyGuard-4B, a lightweight guardrail model that delivers strong detection accuracy across all tasks while keeping inference efficient. Notably, PolicyGuard-4B generalizes across domains and preserves high accuracy on unseen settings. Together, PolicyGuardBench and PolicyGuard-4B provide the first comprehensive framework for studying policy compliance in web agent trajectories, and show that accurate and generalizable guardrails are feasible at small scales.

  • 5 authors
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Oct 3

MCP-Universe: Benchmarking Large Language Models with Real-World Model Context Protocol Servers

The Model Context Protocol has emerged as a transformative standard for connecting large language models to external data sources and tools, rapidly gaining adoption across major AI providers and development platforms. However, existing benchmarks are overly simplistic and fail to capture real application challenges such as long-horizon reasoning and large, unfamiliar tool spaces. To address this critical gap, we introduce MCP-Universe, the first comprehensive benchmark specifically designed to evaluate LLMs in realistic and hard tasks through interaction with real-world MCP servers. Our benchmark encompasses 6 core domains spanning 11 different MCP servers: Location Navigation, Repository Management, Financial Analysis, 3D Design, Browser Automation, and Web Searching. To ensure rigorous evaluation, we implement execution-based evaluators, including format evaluators for agent format compliance, static evaluators for time-invariant content matching, and dynamic evaluators that automatically retrieve real-time ground truth for temporally sensitive tasks. Through extensive evaluation of leading LLMs, we find that even SOTA models such as GPT-5 (43.72%), Grok-4 (33.33%) and Claude-4.0-Sonnet (29.44%) exhibit significant performance limitations. In addition, our benchmark poses a significant long-context challenge for LLM agents, as the number of input tokens increases rapidly with the number of interaction steps. Moreover, it introduces an unknown-tools challenge, as LLM agents often lack familiarity with the precise usage of the MCP servers. Notably, enterprise-level agents like Cursor cannot achieve better performance than standard ReAct frameworks. Beyond evaluation, we open-source our extensible evaluation framework with UI support, enabling researchers and practitioners to seamlessly integrate new agents and MCP servers while fostering innovation in the rapidly evolving MCP ecosystem.

  • 10 authors
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Aug 20 10

HarmonyGuard: Toward Safety and Utility in Web Agents via Adaptive Policy Enhancement and Dual-Objective Optimization

Large language models enable agents to autonomously perform tasks in open web environments. However, as hidden threats within the web evolve, web agents face the challenge of balancing task performance with emerging risks during long-sequence operations. Although this challenge is critical, current research remains limited to single-objective optimization or single-turn scenarios, lacking the capability for collaborative optimization of both safety and utility in web environments. To address this gap, we propose HarmonyGuard, a multi-agent collaborative framework that leverages policy enhancement and objective optimization to jointly improve both utility and safety. HarmonyGuard features a multi-agent architecture characterized by two fundamental capabilities: (1) Adaptive Policy Enhancement: We introduce the Policy Agent within HarmonyGuard, which automatically extracts and maintains structured security policies from unstructured external documents, while continuously updating policies in response to evolving threats. (2) Dual-Objective Optimization: Based on the dual objectives of safety and utility, the Utility Agent integrated within HarmonyGuard performs the Markovian real-time reasoning to evaluate the objectives and utilizes metacognitive capabilities for their optimization. Extensive evaluations on multiple benchmarks show that HarmonyGuard improves policy compliance by up to 38% and task completion by up to 20% over existing baselines, while achieving over 90% policy compliance across all tasks. Our project is available here: https://github.com/YurunChen/HarmonyGuard.

FinReflectKG: Agentic Construction and Evaluation of Financial Knowledge Graphs

The financial domain poses unique challenges for knowledge graph (KG) construction at scale due to the complexity and regulatory nature of financial documents. Despite the critical importance of structured financial knowledge, the field lacks large-scale, open-source datasets capturing rich semantic relationships from corporate disclosures. We introduce an open-source, large-scale financial knowledge graph dataset built from the latest annual SEC 10-K filings of all S and P 100 companies - a comprehensive resource designed to catalyze research in financial AI. We propose a robust and generalizable knowledge graph (KG) construction framework that integrates intelligent document parsing, table-aware chunking, and schema-guided iterative extraction with a reflection-driven feedback loop. Our system incorporates a comprehensive evaluation pipeline, combining rule-based checks, statistical validation, and LLM-as-a-Judge assessments to holistically measure extraction quality. We support three extraction modes - single-pass, multi-pass, and reflection-agent-based - allowing flexible trade-offs between efficiency, accuracy, and reliability based on user requirements. Empirical evaluations demonstrate that the reflection-agent-based mode consistently achieves the best balance, attaining a 64.8 percent compliance score against all rule-based policies (CheckRules) and outperforming baseline methods (single-pass and multi-pass) across key metrics such as precision, comprehensiveness, and relevance in LLM-guided evaluations.

  • 5 authors
·
Aug 25 1

Experimenting with Multi-Agent Software Development: Towards a Unified Platform

Large language models are redefining software engineering by implementing AI-powered techniques throughout the whole software development process, including requirement gathering, software architecture, code generation, testing, and deployment. However, it is still difficult to develop a cohesive platform that consistently produces the best outcomes across all stages. The objective of this study is to develop a unified platform that utilizes multiple artificial intelligence agents to automate the process of transforming user requirements into well-organized deliverables. These deliverables include user stories, prioritization, and UML sequence diagrams, along with the modular approach to APIs, unit tests, and end-to-end tests. Additionally, the platform will organize tasks, perform security and compliance, and suggest design patterns and improvements for non-functional requirements. We allow users to control and manage each phase according to their preferences. In addition, the platform provides security and compliance checks following European standards and proposes design optimizations. We use multiple models, such as GPT-3.5, GPT-4, and Llama3 to enable to generation of modular code as per user choice. The research also highlights the limitations and future research discussions to overall improve the software development life cycle. The source code for our uniform platform is hosted on GitHub, enabling additional experimentation and supporting both research and practical uses. \end

  • 6 authors
·
Jun 8, 2024

Agentar-Fin-R1: Enhancing Financial Intelligence through Domain Expertise, Training Efficiency, and Advanced Reasoning

Large Language Models (LLMs) exhibit considerable promise in financial applications; however, prevailing models frequently demonstrate limitations when confronted with scenarios that necessitate sophisticated reasoning capabilities, stringent trustworthiness criteria, and efficient adaptation to domain-specific requirements. We introduce the Agentar-Fin-R1 series of financial large language models (8B and 32B parameters), specifically engineered based on the Qwen3 foundation model to enhance reasoning capabilities, reliability, and domain specialization for financial applications. Our optimization approach integrates a high-quality, systematic financial task label system with a comprehensive multi-layered trustworthiness assurance framework. This framework encompasses high-quality trustworthy knowledge engineering, multi-agent trustworthy data synthesis, and rigorous data validation governance. Through label-guided automated difficulty-aware optimization, tow-stage training pipeline, and dynamic attribution systems, we achieve substantial improvements in training efficiency. Our models undergo comprehensive evaluation on mainstream financial benchmarks including Fineva, FinEval, and FinanceIQ, as well as general reasoning datasets such as MATH-500 and GPQA-diamond. To thoroughly assess real-world deployment capabilities, we innovatively propose the Finova evaluation benchmark, which focuses on agent-level financial reasoning and compliance verification. Experimental results demonstrate that Agentar-Fin-R1 not only achieves state-of-the-art performance on financial tasks but also exhibits exceptional general reasoning capabilities, validating its effectiveness as a trustworthy solution for high-stakes financial applications. The Finova bench is available at https://github.com/antgroup/Finova.

VeriGuard: Enhancing LLM Agent Safety via Verified Code Generation

The deployment of autonomous AI agents in sensitive domains, such as healthcare, introduces critical risks to safety, security, and privacy. These agents may deviate from user objectives, violate data handling policies, or be compromised by adversarial attacks. Mitigating these dangers necessitates a mechanism to formally guarantee that an agent's actions adhere to predefined safety constraints, a challenge that existing systems do not fully address. We introduce VeriGuard, a novel framework that provides formal safety guarantees for LLM-based agents through a dual-stage architecture designed for robust and verifiable correctness. The initial offline stage involves a comprehensive validation process. It begins by clarifying user intent to establish precise safety specifications. VeriGuard then synthesizes a behavioral policy and subjects it to both testing and formal verification to prove its compliance with these specifications. This iterative process refines the policy until it is deemed correct. Subsequently, the second stage provides online action monitoring, where VeriGuard operates as a runtime monitor to validate each proposed agent action against the pre-verified policy before execution. This separation of the exhaustive offline validation from the lightweight online monitoring allows formal guarantees to be practically applied, providing a robust safeguard that substantially improves the trustworthiness of LLM agents.

google Google
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Oct 3 2

TRiSM for Agentic AI: A Review of Trust, Risk, and Security Management in LLM-based Agentic Multi-Agent Systems

Agentic AI systems, built on large language models (LLMs) and deployed in multi-agent configurations, are redefining intelligent autonomy, collaboration and decision-making across enterprise and societal domains. This review presents a structured analysis of Trust, Risk, and Security Management (TRiSM) in the context of LLM-based agentic multi-agent systems (AMAS). We begin by examining the conceptual foundations of agentic AI, its architectural differences from traditional AI agents, and the emerging system designs that enable scalable, tool-using autonomy. The TRiSM in the agentic AI framework is then detailed through four pillars governance, explainability, ModelOps, and privacy/security each contextualized for agentic LLMs. We identify unique threat vectors and introduce a comprehensive risk taxonomy for the agentic AI applications, supported by case studies illustrating real-world vulnerabilities. Furthermore, the paper also surveys trust-building mechanisms, transparency and oversight techniques, and state-of-the-art explainability strategies in distributed LLM agent systems. Additionally, metrics for evaluating trust, interpretability, and human-centered performance are reviewed alongside open benchmarking challenges. Security and privacy are addressed through encryption, adversarial defense, and compliance with evolving AI regulations. The paper concludes with a roadmap for responsible agentic AI, proposing research directions to align emerging multi-agent systems with robust TRiSM principles for safe, accountable, and transparent deployment.

  • 4 authors
·
Jun 4 2

AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments

Diagnosing and managing a patient is a complex, sequential decision making process that requires physicians to obtain information -- such as which tests to perform -- and to act upon it. Recent advances in artificial intelligence (AI) and large language models (LLMs) promise to profoundly impact clinical care. However, current evaluation schemes overrely on static medical question-answering benchmarks, falling short on interactive decision-making that is required in real-life clinical work. Here, we present AgentClinic: a multimodal benchmark to evaluate LLMs in their ability to operate as agents in simulated clinical environments. In our benchmark, the doctor agent must uncover the patient's diagnosis through dialogue and active data collection. We present two open medical agent benchmarks: a multimodal image and dialogue environment, AgentClinic-NEJM, and a dialogue-only environment, AgentClinic-MedQA. We embed cognitive and implicit biases both in patient and doctor agents to emulate realistic interactions between biased agents. We find that introducing bias leads to large reductions in diagnostic accuracy of the doctor agents, as well as reduced compliance, confidence, and follow-up consultation willingness in patient agents. Evaluating a suite of state-of-the-art LLMs, we find that several models that excel in benchmarks like MedQA are performing poorly in AgentClinic-MedQA. We find that the LLM used in the patient agent is an important factor for performance in the AgentClinic benchmark. We show that both having limited interactions as well as too many interaction reduces diagnostic accuracy in doctor agents. The code and data for this work is publicly available at https://AgentClinic.github.io.

  • 6 authors
·
May 13, 2024

AgentSpec: Customizable Runtime Enforcement for Safe and Reliable LLM Agents

Agents built on LLMs are increasingly deployed across diverse domains, automating complex decision-making and task execution. However, their autonomy introduces safety risks, including security vulnerabilities, legal violations, and unintended harmful actions. Existing mitigation methods, such as model-based safeguards and early enforcement strategies, fall short in robustness, interpretability, and adaptability. To address these challenges, we propose AgentSpec, a lightweight domain-specific language for specifying and enforcing runtime constraints on LLM agents. With AgentSpec, users define structured rules that incorporate triggers, predicates, and enforcement mechanisms, ensuring agents operate within predefined safety boundaries. We implement AgentSpec across multiple domains, including code execution, embodied agents, and autonomous driving, demonstrating its adaptability and effectiveness. Our evaluation shows that AgentSpec successfully prevents unsafe executions in over 90% of code agent cases, eliminates all hazardous actions in embodied agent tasks, and enforces 100% compliance by autonomous vehicles (AVs). Despite its strong safety guarantees, AgentSpec remains computationally lightweight, with overheads in milliseconds. By combining interpretability, modularity, and efficiency, AgentSpec provides a practical and scalable solution for enforcing LLM agent safety across diverse applications. We also automate the generation of rules using LLMs and assess their effectiveness. Our evaluation shows that the rules generated by OpenAI o1 achieve a precision of 95.56% and recall of 70.96% for embodied agents, successfully identify 87.26% of the risky code, and prevent AVs from breaking laws in 5 out of 8 scenarios.

  • 3 authors
·
Mar 24

Toward Agentic AI: Generative Information Retrieval Inspired Intelligent Communications and Networking

The increasing complexity and scale of modern telecommunications networks demand intelligent automation to enhance efficiency, adaptability, and resilience. Agentic AI has emerged as a key paradigm for intelligent communications and networking, enabling AI-driven agents to perceive, reason, decide, and act within dynamic networking environments. However, effective decision-making in telecom applications, such as network planning, management, and resource allocation, requires integrating retrieval mechanisms that support multi-hop reasoning, historical cross-referencing, and compliance with evolving 3GPP standards. This article presents a forward-looking perspective on generative information retrieval-inspired intelligent communications and networking, emphasizing the role of knowledge acquisition, processing, and retrieval in agentic AI for telecom systems. We first provide a comprehensive review of generative information retrieval strategies, including traditional retrieval, hybrid retrieval, semantic retrieval, knowledge-based retrieval, and agentic contextual retrieval. We then analyze their advantages, limitations, and suitability for various networking scenarios. Next, we present a survey about their applications in communications and networking. Additionally, we introduce an agentic contextual retrieval framework to enhance telecom-specific planning by integrating multi-source retrieval, structured reasoning, and self-reflective validation. Experimental results demonstrate that our framework significantly improves answer accuracy, explanation consistency, and retrieval efficiency compared to traditional and semantic retrieval methods. Finally, we outline future research directions.

  • 8 authors
·
Feb 24

Agents Are All You Need for LLM Unlearning

Information removal or suppression in large language models (LLMs) is a desired functionality, useful in AI regulation, legal compliance, safety, and privacy. LLM unlearning methods aim to remove information on demand from LLMs. Current LLM unlearning methods struggle to balance the unlearning efficacy and utility due to the competing nature of these objectives. Keeping the unlearning process computationally feasible without assuming access to the model weights is an overlooked area. In this work we show that agents might be all we need for effective and practical inference-time LLM unlearning. We present the first agentic LLM unlearning (ALU) method, a multi-agent, retrain-free, model-agnostic approach to LLM unlearning that achieves effective unlearning while preserving the utility. Our ALU framework unlearns by involving multiple LLM agents, each designed for a specific step in the unlearning process, without the need to update model weights for any of the agents in the framework. Users can easily request any set of unlearning instances in any sequence, and ALU seamlessly adapts in real time. This is facilitated without requiring any changes in the underlying LLM model. Through extensive experiments on established benchmarks (TOFU, WMDP, WPU) and jailbreaking techniques (many shot, target masking, other languages), we demonstrate that ALU consistently stands out as the most robust inference-time LLM unlearning framework among current state-of-the-art methods while incurring time cost that remains effectively constant regardless of the number of unlearning targets. We further highlight ALU's superior performance compared to existing methods when evaluated at scale. Specifically, ALU is assessed on up to 1000 unlearning targets, exceeding the evaluation scope of all previously proposed LLM unlearning methods.

  • 2 authors
·
Feb 1

LibVulnWatch: A Deep Assessment Agent System and Leaderboard for Uncovering Hidden Vulnerabilities in Open-Source AI Libraries

Open-source AI libraries are foundational to modern AI systems but pose significant, underexamined risks across security, licensing, maintenance, supply chain integrity, and regulatory compliance. We present LibVulnWatch, a graph-based agentic assessment framework that performs deep, source-grounded evaluations of these libraries. Built on LangGraph, the system coordinates a directed acyclic graph of specialized agents to extract, verify, and quantify risk using evidence from trusted sources such as repositories, documentation, and vulnerability databases. LibVulnWatch generates reproducible, governance-aligned scores across five critical domains, publishing them to a public leaderboard for longitudinal ecosystem monitoring. Applied to 20 widely used libraries, including ML frameworks, LLM inference engines, and agent orchestration tools, our system covers up to 88% of OpenSSF Scorecard checks while uncovering up to 19 additional risks per library. These include critical Remote Code Execution (RCE) vulnerabilities, absent Software Bills of Materials (SBOMs), licensing constraints, undocumented telemetry, and widespread gaps in regulatory documentation and auditability. By translating high-level governance principles into practical, verifiable metrics, LibVulnWatch advances technical AI governance with a scalable, transparent mechanism for continuous supply chain risk assessment and informed library selection.

  • 10 authors
·
May 13

ST-WebAgentBench: A Benchmark for Evaluating Safety and Trustworthiness in Web Agents

Recent advancements in Web agents have introduced novel architectures and benchmarks showcasing progress in autonomous web navigation and interaction. However, most existing benchmarks prioritize effectiveness and accuracy, overlooking factors like safety and trustworthiness which are essential for deploying web agents in enterprise settings. We present STWebAgentBench, a benchmark designed to evaluate web agents safety and trustworthiness across six critical dimensions, essential for reliability in enterprise applications. This benchmark is grounded in a detailed framework that defines safe and trustworthy (ST) agent behavior. Our work extends WebArena with safety templates and evaluation functions to assess safety policy compliance rigorously. We introduce the Completion Under Policy to measure task success while adhering to policies, alongside the Risk Ratio, which quantifies policy violations across dimensions, providing actionable insights to address safety gaps. Our evaluation reveals that current SOTA agents struggle with policy adherence and cannot yet be relied upon for critical business applications. We open-source this benchmark and invite the community to contribute, with the goal of fostering a new generation of safer, more trustworthy AI agents. All code, data, environment reproduction resources, and video demonstrations are available at https://sites.google.com/view/st-webagentbench/home.

  • 6 authors
·
Oct 9, 2024

FinRobot: Generative Business Process AI Agents for Enterprise Resource Planning in Finance

Enterprise Resource Planning (ERP) systems serve as the digital backbone of modern financial institutions, yet they continue to rely on static, rule-based workflows that limit adaptability, scalability, and intelligence. As business operations grow more complex and data-rich, conventional ERP platforms struggle to integrate structured and unstructured data in real time and to accommodate dynamic, cross-functional workflows. In this paper, we present the first AI-native, agent-based framework for ERP systems, introducing a novel architecture of Generative Business Process AI Agents (GBPAs) that bring autonomy, reasoning, and dynamic optimization to enterprise workflows. The proposed system integrates generative AI with business process modeling and multi-agent orchestration, enabling end-to-end automation of complex tasks such as budget planning, financial reporting, and wire transfer processing. Unlike traditional workflow engines, GBPAs interpret user intent, synthesize workflows in real time, and coordinate specialized sub-agents for modular task execution. We validate the framework through case studies in bank wire transfers and employee reimbursements, two representative financial workflows with distinct complexity and data modalities. Results show that GBPAs achieve up to 40% reduction in processing time, 94% drop in error rate, and improved regulatory compliance by enabling parallelism, risk control insertion, and semantic reasoning. These findings highlight the potential of GBPAs to bridge the gap between generative AI capabilities and enterprise-grade automation, laying the groundwork for the next generation of intelligent ERP systems.

  • 8 authors
·
Jun 2

Diverse And Private Synthetic Datasets Generation for RAG evaluation: A multi-agent framework

Retrieval-augmented generation (RAG) systems improve large language model outputs by incorporating external knowledge, enabling more informed and context-aware responses. However, the effectiveness and trustworthiness of these systems critically depends on how they are evaluated, particularly on whether the evaluation process captures real-world constraints like protecting sensitive information. While current evaluation efforts for RAG systems have primarily focused on the development of performance metrics, far less attention has been given to the design and quality of the underlying evaluation datasets, despite their pivotal role in enabling meaningful, reliable assessments. In this work, we introduce a novel multi-agent framework for generating synthetic QA datasets for RAG evaluation that prioritize semantic diversity and privacy preservation. Our approach involves: (1) a Diversity agent leveraging clustering techniques to maximize topical coverage and semantic variability, (2) a Privacy Agent that detects and mask sensitive information across multiple domains and (3) a QA curation agent that synthesizes private and diverse QA pairs suitable as ground truth for RAG evaluation. Extensive experiments demonstrate that our evaluation sets outperform baseline methods in diversity and achieve robust privacy masking on domain-specific datasets. This work offers a practical and ethically aligned pathway toward safer, more comprehensive RAG system evaluation, laying the foundation for future enhancements aligned with evolving AI regulations and compliance standards.

  • 3 authors
·
Aug 26

TxAgent: An AI Agent for Therapeutic Reasoning Across a Universe of Tools

Precision therapeutics require multimodal adaptive models that generate personalized treatment recommendations. We introduce TxAgent, an AI agent that leverages multi-step reasoning and real-time biomedical knowledge retrieval across a toolbox of 211 tools to analyze drug interactions, contraindications, and patient-specific treatment strategies. TxAgent evaluates how drugs interact at molecular, pharmacokinetic, and clinical levels, identifies contraindications based on patient comorbidities and concurrent medications, and tailors treatment strategies to individual patient characteristics. It retrieves and synthesizes evidence from multiple biomedical sources, assesses interactions between drugs and patient conditions, and refines treatment recommendations through iterative reasoning. It selects tools based on task objectives and executes structured function calls to solve therapeutic tasks that require clinical reasoning and cross-source validation. The ToolUniverse consolidates 211 tools from trusted sources, including all US FDA-approved drugs since 1939 and validated clinical insights from Open Targets. TxAgent outperforms leading LLMs, tool-use models, and reasoning agents across five new benchmarks: DrugPC, BrandPC, GenericPC, TreatmentPC, and DescriptionPC, covering 3,168 drug reasoning tasks and 456 personalized treatment scenarios. It achieves 92.1% accuracy in open-ended drug reasoning tasks, surpassing GPT-4o and outperforming DeepSeek-R1 (671B) in structured multi-step reasoning. TxAgent generalizes across drug name variants and descriptions. By integrating multi-step inference, real-time knowledge grounding, and tool-assisted decision-making, TxAgent ensures that treatment recommendations align with established clinical guidelines and real-world evidence, reducing the risk of adverse events and improving therapeutic decision-making.

  • 8 authors
·
Mar 13 3

Compliance Cards: Computational Artifacts for Automated AI Regulation Compliance

As the artificial intelligence (AI) supply chain grows more complex, AI systems and models are increasingly likely to incorporate externally-sourced ingredients such as datasets and other models. In such cases, determining whether or not an AI system or model complies with the EU AI Act will require gathering compliance-related metadata about both the AI system or model at-large as well as those externally-supplied ingredients. There must then be an analysis that looks across all of this metadata to render a prediction about the compliance of the overall AI system or model. Up until now, this process has not been automated. Thus, it has not been possible to make real-time compliance determinations in scenarios where doing so would be advantageous, such as the iterative workflows of today's AI developers, search and acquisition of AI ingredients on communities like Hugging Face, federated and continuous learning, and more. To address this shortcoming, we introduce a highly automated system for AI Act compliance analysis. This system has two key elements. First is an interlocking set of computational artifacts that capture compliance-related metadata about both: (1) the AI system or model at-large; (2) any constituent ingredients such as datasets and models. Second is an automated analysis algorithm that operates across those computational artifacts to render a run-time prediction about whether or not the overall AI system or model complies with the AI Act. Working together, these elements promise to enhance and accelerate AI Act compliance assessments.

  • 7 authors
·
Jun 20, 2024